EEG activities in the orbitofrontal cortex and dorsolateral prefrontal cortex during the development of morphine dependence, tolerance and withdrawal in rhesus monkeys

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	EEG activities in the orbitofrontal cortex and dorsolateral prefrontal cortex during the development of morphine dependence, tolerance and withdrawal in rhesus monkeys
	Liu N 1,3,4; Liu YC 2; Fan YD 2; Yu HL 2; Wilson FAW 1,3; Ma YY1,3; Hu XT1,3; yuanma@hotmail.com
	2005
发表期刊	BRAIN RESEARCH
ISSN	0006-8993
卷号	1053 期号:1-2 页码:137-145
合作性质	其它
摘要	Investigating the activities of the prefrontal cortex (PFC) in the process of addiction is valuable for understanding the neural mechanism underlying the impairments of the PFC after drug abuse. However, limited data are obtained from primate animals and few studies analyze Electroencephalogram (EEG) in the gamma band, which plays an important role in cognitive functions. In addition, it is yet unclear whether drug abuse affects the orbitofrontal cortex (OFC) and dorsolateral PFC (DLPFC)--the two most important subregions of the PFC--in similar ways or not. The aim of this study is to address these issues. We recorded EEG in the OFC and DLPFC in three rhesus monkeys. All animals received a course of saline (NaCl 0.9%, 2 ml) injection (5 days) followed by 10 days of morphine injection (every 12 h), and then a further series of saline injection (7 days). A main finding in the present study was that morphine decreased EEG power in all frequency bands in a short period after injection in both the OFC and DLPFC in monkeys. And gamma power decreased not just in a short period after morphine injection but lasted to 12 h after injection. Moreover, we found that although the changes in EEG activities in the OFC and DLPFC at 30-35 min after injection were similar, the DLPFC was more sensitive to the effect of morphine than the OFC.
关键词	Addiction Prefrontal Cortex Morphine Monkeys Eeg
学科领域	Neurosciences
资助者	This work was supported by Chinese Academy of Science Grants (KSCX2-SW for M.Y.), National Basic Research Program of China, Chinese National Science Foundation (30470553) and Program of Chinese Academy of Science (KJCX1-01). We gratefully acknowledge the expert techni- cal assistance by S.H. Tian, S. Yu and S.W. Tian. ; This work was supported by Chinese Academy of Science Grants (KSCX2-SW for M.Y.), National Basic Research Program of China, Chinese National Science Foundation (30470553) and Program of Chinese Academy of Science (KJCX1-01). We gratefully acknowledge the expert techni- cal assistance by S.H. Tian, S. Yu and S.W. Tian. ; This work was supported by Chinese Academy of Science Grants (KSCX2-SW for M.Y.), National Basic Research Program of China, Chinese National Science Foundation (30470553) and Program of Chinese Academy of Science (KJCX1-01). We gratefully acknowledge the expert techni- cal assistance by S.H. Tian, S. Yu and S.W. Tian. ; This work was supported by Chinese Academy of Science Grants (KSCX2-SW for M.Y.), National Basic Research Program of China, Chinese National Science Foundation (30470553) and Program of Chinese Academy of Science (KJCX1-01). We gratefully acknowledge the expert techni- cal assistance by S.H. Tian, S. Yu and S.W. Tian.
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收录类别	SCI
语种	英语
资助者	This work was supported by Chinese Academy of Science Grants (KSCX2-SW for M.Y.), National Basic Research Program of China, Chinese National Science Foundation (30470553) and Program of Chinese Academy of Science (KJCX1-01). We gratefully acknowledge the expert techni- cal assistance by S.H. Tian, S. Yu and S.W. Tian. ; This work was supported by Chinese Academy of Science Grants (KSCX2-SW for M.Y.), National Basic Research Program of China, Chinese National Science Foundation (30470553) and Program of Chinese Academy of Science (KJCX1-01). We gratefully acknowledge the expert techni- cal assistance by S.H. Tian, S. Yu and S.W. Tian. ; This work was supported by Chinese Academy of Science Grants (KSCX2-SW for M.Y.), National Basic Research Program of China, Chinese National Science Foundation (30470553) and Program of Chinese Academy of Science (KJCX1-01). We gratefully acknowledge the expert techni- cal assistance by S.H. Tian, S. Yu and S.W. Tian. ; This work was supported by Chinese Academy of Science Grants (KSCX2-SW for M.Y.), National Basic Research Program of China, Chinese National Science Foundation (30470553) and Program of Chinese Academy of Science (KJCX1-01). We gratefully acknowledge the expert techni- cal assistance by S.H. Tian, S. Yu and S.W. Tian.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5439
专题	认知障碍病理学科研部门_神经系统编码（胡新天）中国科学院昆明灵长类研究中心
通讯作者	yuanma@hotmail.com
作者单位	1.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, P.R. China 2.Kunming Medical College, Kunming, 650223, P.R. China 3.Kunming Primate Center, Chinese Academy of Sciences, Kunming, 650223, P.R. China 4.Graduate School of the Chinese Academy of Science, Beijing 100039, P.R. China
推荐引用方式 GB/T 7714	Liu N,Liu YC,Fan YD,et al. EEG activities in the orbitofrontal cortex and dorsolateral prefrontal cortex during the development of morphine dependence, tolerance and withdrawal in rhesus monkeys[J]. BRAIN RESEARCH,2005,1053(1-2):137-145.
APA	Liu N.,Liu YC.,Fan YD.,Yu HL.,Wilson FAW.,...&yuanma@hotmail.com.(2005).EEG activities in the orbitofrontal cortex and dorsolateral prefrontal cortex during the development of morphine dependence, tolerance and withdrawal in rhesus monkeys.BRAIN RESEARCH,1053(1-2),137-145.
MLA	Liu N,et al."EEG activities in the orbitofrontal cortex and dorsolateral prefrontal cortex during the development of morphine dependence, tolerance and withdrawal in rhesus monkeys".BRAIN RESEARCH 1053.1-2(2005):137-145.

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