Maze model to study spatial learning and memory in freely moving monkeys

KIZ OpenIR > 认知障碍病理学

	Maze model to study spatial learning and memory in freely moving monkeys
	Zhang B 1,2,5; Tan H 4; Sun NL 1,2,5; Wang JH 1,2,5; Meng ZQ 1,2,5; Li CY 6; Fraser WAW 1,2; Hu XT2,3,9; Carlson S 7; Ma YY1,8,9; xthu@mail.kiz.ac.cn ; yuanma07l6@vip.sina.com
	2008
发表期刊	JOURNAL OF NEUROSCIENCE METHODS
ISSN	0165-0270
卷号	170 期号:1 页码:111-116
摘要	Many types of mazes have been used in cognitive brain research and data obtained from those experiments, especially those from rodents' studies, support the idea that the hippocampus is related to spatial learning and memory. But the results from non-human primates researches regarding the role of the hippocampus in spatial learning and memory are controversial and inconsistent with those obtained in rodents. This might be due to the differences of the methods used in non-human primates and rodents. Several kinds of maze models including two-dimensional computerized visual maze models and three-dimensional maze models have been developed for non-human primates, but they all have some defects. Therefore, development of a maze model for non-human primates that is comparable with those used in rodents is necessary to solve the controversy. This paper describes a large-scale, three-dimensional outdoor maze model for non-human primates which can be used to study spatial learning and memory. Monkeys learn to use the maze quickly compared with two-dimensional computerized visual mazes. It has many advantages which could make up the limits of the existing three-dimensional mazes in non-human primates, and can be comparable with radial arm mazes used in rodents. Based on the results, we believe that the new maze model will be valuable in many research areas, especially in studies involving spatial learning and memory in freely moving monkeys.
关键词	Three-dimensional Maze Spatial Learning And Memory Freely Moving Monkeys
资助者	This study was supported by National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810, 2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese-Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33, YZ200737), National Key Technologies R&D Program and Yunnan Science and Technique Program (2006PT08-2). ; This study was supported by National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810, 2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese-Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33, YZ200737), National Key Technologies R&D Program and Yunnan Science and Technique Program (2006PT08-2). ; This study was supported by National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810, 2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese-Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33, YZ200737), National Key Technologies R&D Program and Yunnan Science and Technique Program (2006PT08-2). ; This study was supported by National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810, 2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese-Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33, YZ200737), National Key Technologies R&D Program and Yunnan Science and Technique Program (2006PT08-2).
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收录类别	SCI
语种	英语
资助者	This study was supported by National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810, 2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese-Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33, YZ200737), National Key Technologies R&D Program and Yunnan Science and Technique Program (2006PT08-2). ; This study was supported by National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810, 2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese-Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33, YZ200737), National Key Technologies R&D Program and Yunnan Science and Technique Program (2006PT08-2). ; This study was supported by National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810, 2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese-Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33, YZ200737), National Key Technologies R&D Program and Yunnan Science and Technique Program (2006PT08-2). ; This study was supported by National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810, 2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese-Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33, YZ200737), National Key Technologies R&D Program and Yunnan Science and Technique Program (2006PT08-2).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5471
专题	认知障碍病理学科研部门_动物模型与人类重大疾病机理重点实验室科研部门_神经系统编码（胡新天）中国科学院昆明灵长类研究中心
通讯作者	xthu@mail.kiz.ac.cn; yuanma07l6@vip.sina.com
作者单位	1.Section of Primate Neuroscience Research Laboratory and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, PR China 2.Laboratory of Sensory-motor Integration Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, PR China 3.Shanghai Institute of Brain Functional, Genomics East China Normal University, 3663 North Zhong Shan Rd, Shanghai 200062, PR China 4.Institute of Bio-inspired Structure and Surface Engineering, The Academy of Frontier Science, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, PR China 5.Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China 6.Department of Physiology, College of Medicine, Nanhua University, Hengyang, Hunan 421001, PR China 7.Neuroscience unit, Institute of Biomedicine/physiology, University of Helsinki, Helsinki, Finland and Medical School, University of Tampere, Tampere, Finland 8.Kunming Primate Research Center, Chinese Academy of Sciences, Kunming, Yunnan, PR China 9.Kunming Biomed International, Kunming, Yunnan, PR China
推荐引用方式 GB/T 7714	Zhang B,Tan H,Sun NL,et al. Maze model to study spatial learning and memory in freely moving monkeys[J]. JOURNAL OF NEUROSCIENCE METHODS,2008,170(1):111-116.
APA	Zhang B.,Tan H.,Sun NL.,Wang JH.,Meng ZQ.,...&yuanma07l6@vip.sina.com.(2008).Maze model to study spatial learning and memory in freely moving monkeys.JOURNAL OF NEUROSCIENCE METHODS,170(1),111-116.
MLA	Zhang B,et al."Maze model to study spatial learning and memory in freely moving monkeys".JOURNAL OF NEUROSCIENCE METHODS 170.1(2008):111-116.

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