Distracters Impair and Create Working Memory-Related Neuronal Activity in the Prefrontal Cortex

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	Distracters Impair and Create Working Memory-Related Neuronal Activity in the Prefrontal Cortex
	Artchakov D 1; Tikhonravov D 1; Ma YY 2; Neuvonen T 1; Linnankoski I 1; Carlson S*1,3,4; syncarls@cc.helsinki.fi
	2009
发表期刊	CEREBRAL CORTEX
ISSN	1047-3211
卷号	19 期号:11 页码:2680-2689
合作性质	其它
摘要	The prefrontal cortex (PFC) has a central role in working memory (WM). Resistance to distraction is considered a fundamental feature of WM and PFC neuronal activity. However, although unexpected stimuli often disrupt our work, little is known about the underlying neuronal mechanisms involved. In the present study, we investigated whether irregularly presented distracters disrupt WM task performance and underlying neuronal activity. We recorded single neuron activity in the PFC of 2 monkeys performing WM tasks and investigated effects of auditory and visual distracters on WM performance and neuronal activity. Distracters impaired memory task performance and affected PFC neuronal activity. Distraction that was of the same sensory modality as the memorandum was more likely to impair WM performance and interfere with memory-related neuronal activity than information that was of a different sensory modality. The study also shows that neurons not involved in memory processing in less demanding conditions may become engaged in WM processing in more demanding conditions. The study demonstrates that WM performance and underlying neuronal activity are vulnerable to irregular distracters and suggests that the PFC has mechanisms that help to compensate for disruptive effects of external distracters.
关键词	Delayed Matching To Sample Distraction Primate Single Cell Working Memory
学科领域	Neurosciences
资助者	Academy of Finland (National Centers of Excellence Program 2006--2011 and Chinese--Finnish Collaboration of the Neuro Program No. 214412); National Science Foundation of China (Chinese--Finnish International Collaboration, Project-neuro No. 30621130076, 30530270) ; Academy of Finland (National Centers of Excellence Program 2006--2011 and Chinese--Finnish Collaboration of the Neuro Program No. 214412); National Science Foundation of China (Chinese--Finnish International Collaboration, Project-neuro No. 30621130076, 30530270) ; Academy of Finland (National Centers of Excellence Program 2006--2011 and Chinese--Finnish Collaboration of the Neuro Program No. 214412); National Science Foundation of China (Chinese--Finnish International Collaboration, Project-neuro No. 30621130076, 30530270) ; Academy of Finland (National Centers of Excellence Program 2006--2011 and Chinese--Finnish Collaboration of the Neuro Program No. 214412); National Science Foundation of China (Chinese--Finnish International Collaboration, Project-neuro No. 30621130076, 30530270)
URL	查看原文
收录类别	SCI
语种	英语
资助者	Academy of Finland (National Centers of Excellence Program 2006--2011 and Chinese--Finnish Collaboration of the Neuro Program No. 214412); National Science Foundation of China (Chinese--Finnish International Collaboration, Project-neuro No. 30621130076, 30530270) ; Academy of Finland (National Centers of Excellence Program 2006--2011 and Chinese--Finnish Collaboration of the Neuro Program No. 214412); National Science Foundation of China (Chinese--Finnish International Collaboration, Project-neuro No. 30621130076, 30530270) ; Academy of Finland (National Centers of Excellence Program 2006--2011 and Chinese--Finnish Collaboration of the Neuro Program No. 214412); National Science Foundation of China (Chinese--Finnish International Collaboration, Project-neuro No. 30621130076, 30530270) ; Academy of Finland (National Centers of Excellence Program 2006--2011 and Chinese--Finnish Collaboration of the Neuro Program No. 214412); National Science Foundation of China (Chinese--Finnish International Collaboration, Project-neuro No. 30621130076, 30530270)
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5487
专题	认知障碍病理学
通讯作者	syncarls@cc.helsinki.fi
作者单位	1.Neuroscience Unit, Institute of Biomedicine/Physiology and Department of Basic Veterinary Sciences/Physiology, University of Helsinki, Finland 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 3.Medical School, University of Tampere, Tampere, Finland 4.Brain Research Unit, Low Temperature Laboratory, Helsinki University of Technology, Espoo, Finland
推荐引用方式 GB/T 7714	Artchakov D,Tikhonravov D,Ma YY,et al. Distracters Impair and Create Working Memory-Related Neuronal Activity in the Prefrontal Cortex[J]. CEREBRAL CORTEX,2009,19(11):2680-2689.
APA	Artchakov D.,Tikhonravov D.,Ma YY.,Neuvonen T.,Linnankoski I.,...&syncarls@cc.helsinki.fi.(2009).Distracters Impair and Create Working Memory-Related Neuronal Activity in the Prefrontal Cortex.CEREBRAL CORTEX,19(11),2680-2689.
MLA	Artchakov D,et al."Distracters Impair and Create Working Memory-Related Neuronal Activity in the Prefrontal Cortex".CEREBRAL CORTEX 19.11(2009):2680-2689.

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