Spatial exploration induces a persistent reversal of long-term potentiation in rat hippocampus

	Spatial exploration induces a persistent reversal of long-term potentiation in rat hippocampus
	Xu L 1,3; Anwyl R 2; Rowan MJ*1; mrowan@mail.tcd.ie
	1998
发表期刊	NATURE
ISSN	0028-0836
卷号	394 期号:6696 页码:891-894
合作性质	其它
摘要	Experience-dependent long-lasting increases in excitatory synaptic transmission in the hippocampus are believed to underlie certain types of memory(1-3). Whereas stimulation of hippocampal pathways in freely moving rats can readily elicit a long-term potentiation (LTP) of transmission that may last for weeks, previous studies have failed to detect persistent increases in synaptic efficacy after hippocampus-mediated learning(4-6). As changes in synaptic efficacy are contingent on the history of plasticity at the synapses(7), we have examined the effect of experience-dependent hippocampal activation on transmission after the induction of LTP, We show that exploration of a new, non-stressful environment rapidly induces a complete and persistent reversal of the expression of high-frequency stimulation-induced early-phase LTP in the CA1 area of the hippocampus, without affecting baseline transmission in a control pathway. LTP expression is not affected by exploration of familiar environments. We found that spatial exploration affected LTP within a defined time window because neither the induction of LTP nor the maintenance of long-established LTP was blocked. The discovery of a novelty-induced reversal of LTP expression provides strong evidence that extensive long-lasting decreases in synaptic efficacy may act in tandem with enhancements at selected synapses to allow the detection and storage of new information by the hippocampus.
资助者	This researchwas supported by the Health Research Board of Ireland, the European Union DGXII and the Wellcome Trust. We thank W. K. Cullen and J. Wu for assistance. ; This researchwas supported by the Health Research Board of Ireland, the European Union DGXII and the Wellcome Trust. We thank W. K. Cullen and J. Wu for assistance. ; This researchwas supported by the Health Research Board of Ireland, the European Union DGXII and the Wellcome Trust. We thank W. K. Cullen and J. Wu for assistance. ; This researchwas supported by the Health Research Board of Ireland, the European Union DGXII and the Wellcome Trust. We thank W. K. Cullen and J. Wu for assistance.
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收录类别	SCI
语种	英语
资助者	This researchwas supported by the Health Research Board of Ireland, the European Union DGXII and the Wellcome Trust. We thank W. K. Cullen and J. Wu for assistance. ; This researchwas supported by the Health Research Board of Ireland, the European Union DGXII and the Wellcome Trust. We thank W. K. Cullen and J. Wu for assistance. ; This researchwas supported by the Health Research Board of Ireland, the European Union DGXII and the Wellcome Trust. We thank W. K. Cullen and J. Wu for assistance. ; This researchwas supported by the Health Research Board of Ireland, the European Union DGXII and the Wellcome Trust. We thank W. K. Cullen and J. Wu for assistance.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5839
专题	科研部门_学习记忆的分子神经机制（徐林）
通讯作者	mrowan@mail.tcd.ie
作者单位	1.Department of Pharmacology and Therapeutics, Trinity College, Dublin 2, Ireland 2.DepartmentofPhysiology, Trinity College, Dublin 2, Ireland 3.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, The People’s Republic of China
推荐引用方式 GB/T 7714	Xu L,Anwyl R,Rowan MJ*,et al. Spatial exploration induces a persistent reversal of long-term potentiation in rat hippocampus[J]. NATURE,1998,394(6696):891-894.
APA	Xu L,Anwyl R,Rowan MJ*,&mrowan@mail.tcd.ie.(1998).Spatial exploration induces a persistent reversal of long-term potentiation in rat hippocampus.NATURE,394(6696),891-894.
MLA	Xu L,et al."Spatial exploration induces a persistent reversal of long-term potentiation in rat hippocampus".NATURE 394.6696(1998):891-894.

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