Glucocorticoid receptor and protein/RNA synthesis-dependent mechanisms underlie the control of synaptic plasticity by stress

	Glucocorticoid receptor and protein/RNA synthesis-dependent mechanisms underlie the control of synaptic plasticity by stress
	Xu L 1,3; Holscher C 1; Anwyl R 2; Rowan MJ[*]1; mrowan@mail.tcd.i.e
	1998
发表期刊	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN	0027-8424
卷号	95 期号:6 页码:3204-3208
合作性质	其它
摘要	Learning and memory are exquisitely sensitive to behavioral stress, but the underlying mechanisms are still poorly understood. Because activity-dependent persistent changes in synaptic strength are believed to mediate memory processes in brain areas such as the hippocampus we have examined the means by which stress affects synaptic plasticity in the CA1 region of the hippocampus of anesthetized rats, Inescapable behavioral stress (placement on an elevated platform for 30 min) switched the direction of plasticity, favoring low frequency stimulation-induced decreases in synaptic transmission (long-term depression, LTD), and opposing the induction of long-term potentiation by high frequency stimulation, We have discovered that glucocorticoid receptor activation mediates these effects of stress on LTD and longterm potentiation in a protein synthesis-dependent manner because they were prevented by the glucocorticoid receptor antagonist RU 38486 and the protein synthesis inhibitor emetine. Consistent with this, the ability of exogenously applied corticosterone in non-stressed rats to mimic the effects of stress on synaptic plasticity was also blocked by these agents, The enablement of low frequency stimulation-induced LTD by both stress and exogenous corticosterone was also blocked by the transcription inhibitor actinomycin D, Thus, naturally occurring synaptic plasticity is liable to be reversed in stressful situations via glucocorticoid receptor activation and mechanisms dependent on the synthesis of new protein and RNA, This indicates that the modulation of hippocampus-mediated learning by acute inescapable stress requires glucocorticoid receptor-dependent initiation of transcription and translation.
关键词	Long-term Potentiation Long-term Depression Memory Storage
资助者	This paper was submitted directly (Track II) to the Proceedings office. Abbreviations: LTD, long-term depression; LTP, long-term potenti- ation; EPSP, excitatory postsynaptic potential; i.c.v., intracerebroven- tricular. ; This paper was submitted directly (Track II) to the Proceedings office. Abbreviations: LTD, long-term depression; LTP, long-term potenti- ation; EPSP, excitatory postsynaptic potential; i.c.v., intracerebroven- tricular. ; This paper was submitted directly (Track II) to the Proceedings office. Abbreviations: LTD, long-term depression; LTP, long-term potenti- ation; EPSP, excitatory postsynaptic potential; i.c.v., intracerebroven- tricular. ; This paper was submitted directly (Track II) to the Proceedings office. Abbreviations: LTD, long-term depression; LTP, long-term potenti- ation; EPSP, excitatory postsynaptic potential; i.c.v., intracerebroven- tricular.
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收录类别	SCI
语种	英语
资助者	This paper was submitted directly (Track II) to the Proceedings office. Abbreviations: LTD, long-term depression; LTP, long-term potenti- ation; EPSP, excitatory postsynaptic potential; i.c.v., intracerebroven- tricular. ; This paper was submitted directly (Track II) to the Proceedings office. Abbreviations: LTD, long-term depression; LTP, long-term potenti- ation; EPSP, excitatory postsynaptic potential; i.c.v., intracerebroven- tricular. ; This paper was submitted directly (Track II) to the Proceedings office. Abbreviations: LTD, long-term depression; LTP, long-term potenti- ation; EPSP, excitatory postsynaptic potential; i.c.v., intracerebroven- tricular. ; This paper was submitted directly (Track II) to the Proceedings office. Abbreviations: LTD, long-term depression; LTP, long-term potenti- ation; EPSP, excitatory postsynaptic potential; i.c.v., intracerebroven- tricular.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5841
专题	科研部门_学习记忆的分子神经机制（徐林）
通讯作者	mrowan@mail.tcd.i.e
作者单位	1.Department of Pharmacology and Therapeutics, Trinity College, Dublin 2, Ireland 2.Physiology, Trinity College, Dublin 2, Ireland 3.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Peoples Republic of China
推荐引用方式 GB/T 7714	Xu L,Holscher C,Anwyl R,et al. Glucocorticoid receptor and protein/RNA synthesis-dependent mechanisms underlie the control of synaptic plasticity by stress[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,1998,95(6):3204-3208.
APA	Xu L,Holscher C,Anwyl R,Rowan MJ[*],&mrowan@mail.tcd.i.e.(1998).Glucocorticoid receptor and protein/RNA synthesis-dependent mechanisms underlie the control of synaptic plasticity by stress.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,95(6),3204-3208.
MLA	Xu L,et al."Glucocorticoid receptor and protein/RNA synthesis-dependent mechanisms underlie the control of synaptic plasticity by stress".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 95.6(1998):3204-3208.

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