Frontal and cingulate gray matter volume reduction in heroin dependence: Optimized voxel-based morphometry

	Frontal and cingulate gray matter volume reduction in heroin dependence: Optimized voxel-based morphometry
	Liu HH 1; Hao YH 1; Kaneko Y 2; Ouyang X 1; Zhang Y 1; Xu L 1,3; Xue ZM1; Liu ZN1; x.zhimin@163.com
	2009
发表期刊	PSYCHIATRY AND CLINICAL NEUROSCIENCES
ISSN	1323-1316
卷号	63 期号:4 页码:563-568
合作性质	其它
摘要	Aims: Repeated exposure to heroin, a typical opiate, causes neuronal adaptation and may result in anatomical changes in specific brain regions, particularly the frontal and limbic cortices. The volume changes of gray matter (GM) of these brain regions, however, have not been identified in heroin addiction. Methods: Using structural magnetic resonance imaging and an optimized voxel-based morphometry approach, the GM volume difference between 15 Chinese heroin-dependent and 15 healthy subjects was tested. Results: Compared to healthy subjects, the heroin-dependent subjects had reduced GM volume in the right prefrontal cortex, left supplementary motor cortex and bilateral cingulate cortices. Conclusion: Frontal and cingulate atrophy may be involved in the neuropathology of heroin dependence.
关键词	Brain Imaging Gray Matter Heroin Voxel-based Morphometry
资助者	The work was supported by grants from the National Natural Science Foundation of China (30530250 to Lin Xu) and 973 Program (2006CB500800 to Lin Xu and 2007CB512308 to Zhening Liu). ; The work was supported by grants from the National Natural Science Foundation of China (30530250 to Lin Xu) and 973 Program (2006CB500800 to Lin Xu and 2007CB512308 to Zhening Liu). ; The work was supported by grants from the National Natural Science Foundation of China (30530250 to Lin Xu) and 973 Program (2006CB500800 to Lin Xu and 2007CB512308 to Zhening Liu). ; The work was supported by grants from the National Natural Science Foundation of China (30530250 to Lin Xu) and 973 Program (2006CB500800 to Lin Xu and 2007CB512308 to Zhening Liu).
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收录类别	SCI
语种	英语
资助者	The work was supported by grants from the National Natural Science Foundation of China (30530250 to Lin Xu) and 973 Program (2006CB500800 to Lin Xu and 2007CB512308 to Zhening Liu). ; The work was supported by grants from the National Natural Science Foundation of China (30530250 to Lin Xu) and 973 Program (2006CB500800 to Lin Xu and 2007CB512308 to Zhening Liu). ; The work was supported by grants from the National Natural Science Foundation of China (30530250 to Lin Xu) and 973 Program (2006CB500800 to Lin Xu and 2007CB512308 to Zhening Liu). ; The work was supported by grants from the National Natural Science Foundation of China (30530250 to Lin Xu) and 973 Program (2006CB500800 to Lin Xu and 2007CB512308 to Zhening Liu).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5931
专题	科研部门_学习记忆的分子神经机制（徐林）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	x.zhimin@163.com
作者单位	1.Mental Health Institute, Second Xiangya Hospital of Central South University, Changsha, Hunan 2.Yale University School of Medicine, New Haven, Connecticut, USA 3.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology of Chinese Academy of Science, Kuming, Yunnan, Chin
推荐引用方式 GB/T 7714	Liu HH,Hao YH,Kaneko Y,et al. Frontal and cingulate gray matter volume reduction in heroin dependence: Optimized voxel-based morphometry[J]. PSYCHIATRY AND CLINICAL NEUROSCIENCES,2009,63(4):563-568.
APA	Liu HH.,Hao YH.,Kaneko Y.,Ouyang X.,Zhang Y.,...&x.zhimin@163.com.(2009).Frontal and cingulate gray matter volume reduction in heroin dependence: Optimized voxel-based morphometry.PSYCHIATRY AND CLINICAL NEUROSCIENCES,63(4),563-568.
MLA	Liu HH,et al."Frontal and cingulate gray matter volume reduction in heroin dependence: Optimized voxel-based morphometry".PSYCHIATRY AND CLINICAL NEUROSCIENCES 63.4(2009):563-568.

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