A call for mtDNA data quality control in forensic science

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	A call for mtDNA data quality control in forensic science
	Yao YG 1,4; Bravi CM 2; Bandelt HJ*3; bandelt@math.uni-hamburg.de
	2004
发表期刊	FORENSIC SCIENCE INTERNATIONAL
ISSN	0379-0738
卷号	141 期号:1 页码:1-6
合作性质	其它
摘要	There is increasing evidence that many of the mitochondrial DNA (mtDNA) databases published in the fields of forensic science and molecular anthropology are flawed. An a posteriori phylogenetic analysis of the sequences could help to eliminate most of the errors and thus greatly improve data quality. However, previously published caveats and recommendations along these lines were not yet picked up by all researchers. Here we call for stringent quality control of mtDNA data by haplogroup-directed database comparisons. We take some problematic databases of East Asian mtDNAs, published in the Journal of Forensic Sciences and Forensic Science International, as examples to demonstrate the process of pinpointing obvious errors. Our results show that data sets are not only notoriously plagued by base shifts and artificial recombination but also by lab-specific phantom mutations, especially in the second hypervariable region (HVR-II).
关键词	Mtdna Typing Hypervariable Regions Phylogeny Haplogroup Quality Control
URL	查看原文
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5977
专题	科研部门_疾病机理遗传学和进化医学学科组（姚永刚）细胞与分子进化开放实验室
通讯作者	bandelt@math.uni-hamburg.de
作者单位	1.Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.Centro de Investigaciones en Genetica Basica y Aplicada, School of Veterinary Sciences, National University of La Plata, La Plata, Argentina 3.Fachbereich Mathematik, Universita¨t Hamburg, Bundesstr. 55, 20146 Hamburg, Germany 4.Present address: The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
推荐引用方式 GB/T 7714	Yao YG,Bravi CM,Bandelt HJ*,et al. A call for mtDNA data quality control in forensic science[J]. FORENSIC SCIENCE INTERNATIONAL,2004,141(1):1-6.
APA	Yao YG,Bravi CM,Bandelt HJ*,&bandelt@math.uni-hamburg.de.(2004).A call for mtDNA data quality control in forensic science.FORENSIC SCIENCE INTERNATIONAL,141(1),1-6.
MLA	Yao YG,et al."A call for mtDNA data quality control in forensic science".FORENSIC SCIENCE INTERNATIONAL 141.1(2004):1-6.

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20041411.pdf（105KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文