The Phylogeny of the Four Pan-American MtDNA Haplogroups: Implications for Evolutionary and Disease Studies

KIZ OpenIR > 科研部门 > 分子人类学（孔庆鹏）

	The Phylogeny of the Four Pan-American MtDNA Haplogroups: Implications for Evolutionary and Disease Studies
	Achilli A 1,2; Perego UA 1,3; Bravi CM 4; Coble MD 5; Kong QP 6,7; Woodward SR 3; Salas A 8; Torroni A*1; Bandelt HJ 9; torroni@ipvgen.unipv.it
	2008
发表期刊	PLOS ONE
卷号	3 期号:3 页码:e1764
合作性质	其它
摘要	Only a limited number of complete mitochondrial genome sequences belonging to Native American haplogroups were available until recently, which left America as the continent with the least amount of information about sequence variation of entire mitochondrial DNAs. In this study, a comprehensive overview of all available complete mitochondrial DNA (mtDNA) genomes of the four pan-American haplogroups A2, B2, C1, and D1 is provided by revising the information scattered throughout GenBank and the literature, and adding 14 novel mtDNA sequences. The phylogenies of haplogroups A2, B2, C1, and D1 reveal a large number of sub-haplogroups but suggest that the ancestral Beringian population(s) contributed only six (successful) founder haplotypes to these haplogroups. The derived clades are overall starlike with coalescence times ranging from 18,000 to 21,000 years (with one exception) using the conventional calibration. The average of about 19,000 years somewhat contrasts with the corresponding lower age of about 13,500 years that was recently proposed by employing a different calibration and estimation approach. Our estimate indicates a human entry and spread of the pan-American haplogroups into the Americas right after the peak of the Last Glacial Maximum and comfortably agrees with the undisputed ages of the earliest Paleoindians in South America. In addition, the phylogenetic approach also indicates that the pathogenic status proposed for various mtDNA mutations, which actually define branches of Native American haplogroups, was based on insufficient grounds.
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资助者	This research received support from Progetti Ricerca Interesse Nazionale 2005 (Italian Ministry of the University) (to AT) and Fondazione Cariplo (to AT). Funding agencies had no role in the design and conduct of the study. ; This research received support from Progetti Ricerca Interesse Nazionale 2005 (Italian Ministry of the University) (to AT) and Fondazione Cariplo (to AT). Funding agencies had no role in the design and conduct of the study. ; This research received support from Progetti Ricerca Interesse Nazionale 2005 (Italian Ministry of the University) (to AT) and Fondazione Cariplo (to AT). Funding agencies had no role in the design and conduct of the study. ; This research received support from Progetti Ricerca Interesse Nazionale 2005 (Italian Ministry of the University) (to AT) and Fondazione Cariplo (to AT). Funding agencies had no role in the design and conduct of the study.
收录类别	SCI
语种	英语
资助者	This research received support from Progetti Ricerca Interesse Nazionale 2005 (Italian Ministry of the University) (to AT) and Fondazione Cariplo (to AT). Funding agencies had no role in the design and conduct of the study. ; This research received support from Progetti Ricerca Interesse Nazionale 2005 (Italian Ministry of the University) (to AT) and Fondazione Cariplo (to AT). Funding agencies had no role in the design and conduct of the study. ; This research received support from Progetti Ricerca Interesse Nazionale 2005 (Italian Ministry of the University) (to AT) and Fondazione Cariplo (to AT). Funding agencies had no role in the design and conduct of the study. ; This research received support from Progetti Ricerca Interesse Nazionale 2005 (Italian Ministry of the University) (to AT) and Fondazione Cariplo (to AT). Funding agencies had no role in the design and conduct of the study.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/6351
专题	科研部门_分子人类学（孔庆鹏）细胞与分子进化开放实验室
通讯作者	torroni@ipvgen.unipv.it
作者单位	1.Dipartimento di Genetica e Microbiologia, Universita ` di Pavia, Pavia, Italy 2.Dipartimento di Biologia Cellulare e Ambientale, Universita ` degli Studi di Perugia, Perugia, Italy 3.Sorenson Molecular Genealogy Foundation, Salt Lake City, Utah, United States of America 4.Laboratorio de Gene ´tica Molecular Poblacional, Instituto Multidisciplinario de Biologı ´a Celular (IMBICE), La Plata, Argentina 5.Armed Forces DNA Identification Laboratory, Armed Forces Institute of Pathology, Rockville, Maryland, United States of America 6.Laboratory of Cellular and Molecular Evolution, and Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 7.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming, China 8.Unidade de Xene ´tica, Instituto de Medicina Legal, Facultad de Medicina, Universidad de Santiago de Compostela, Grupo de Medicina Xeno ´mica, Hospital Clı ´nico Universitario, Santiago de Compostela, Galicia, Spain 9.Department of Mathematics, University of Hamburg, Hamburg, Germany
推荐引用方式 GB/T 7714	Achilli A,Perego UA,Bravi CM,et al. The Phylogeny of the Four Pan-American MtDNA Haplogroups: Implications for Evolutionary and Disease Studies[J]. PLOS ONE,2008,3(3):e1764.
APA	Achilli A.,Perego UA.,Bravi CM.,Coble MD.,Kong QP.,...&torroni@ipvgen.unipv.it.(2008).The Phylogeny of the Four Pan-American MtDNA Haplogroups: Implications for Evolutionary and Disease Studies.PLOS ONE,3(3),e1764.
MLA	Achilli A,et al."The Phylogeny of the Four Pan-American MtDNA Haplogroups: Implications for Evolutionary and Disease Studies".PLOS ONE 3.3(2008):e1764.

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