| Immune Responses to Six Synthetic Peptides of Capsid Protein Immune Responses to Six Synthetic Peptides of Capsid Protein | |
| Liu GJ1; Yang LM1; Wang JH1,2; Zhang GH1,2; Chen XM1; Zheng YT*1; zhengyt@mail.kiz.ac.cn | |
| 2005 | |
| 发表期刊 | CELLULAR & MOLECULAR IMMUNOLOGY
 |
| 卷号 | 2期号:4页码:289-293 |
| 合作性质 | 其它 |
| 摘要 | Many B cell epitopes within p24 of human immunodeficiency virus type 1 (HIV-1) were identified, while most of them were determined by using murine monoclonal antibodies reacting with overlapping peptides of p24. Therefore these epitopes may not represent the actual epitopes recognized by the HIV-1 infected individuals. In the present study, immune responses of 67 HIV-1 positive sera from Yunnan Province, China to five peptides on p24 of HIV-1 and one of HIV-2 were analyzed. All of 67 sera did not recognize peptide GA-12 on HIV-1 and peptide AG-23 on HIV-2, which indicated that GA-12 was not human B cell epitope and AG-23 did not cross-react with HIV-1 positive serum. Except 13 sera (19.4%), all remaining sera did not recognize peptides NI-15, DR-16, DC-22 and PS-18, which indicated that these four peptides represented B cell linear epitopes of HIV-1 p24 in some HIV-1 infected individuals but not the immuno-dominant epitopes in most individuals. |
| 关键词 | Hiv-1 Human Serum Immune Response P24 Synthetic Peptid |
| 资助者 | The work was supported by grants from the National Natural Science Foundation of China (39500137), the Natural Science Foundation of Yunnan (95C0099Q), Key Scientific and Technological projects of China (2004BA719A14) and Yunnan (2004NG12), CAS Projects (STZ-01-17; KSCX2- SW-216; KSCX1-SW-11), and National 863 Program (2003AA219142). ; The work was supported by grants from the National Natural Science Foundation of China (39500137), the Natural Science Foundation of Yunnan (95C0099Q), Key Scientific and Technological projects of China (2004BA719A14) and Yunnan (2004NG12), CAS Projects (STZ-01-17; KSCX2- SW-216; KSCX1-SW-11), and National 863 Program (2003AA219142). ; The work was supported by grants from the National Natural Science Foundation of China (39500137), the Natural Science Foundation of Yunnan (95C0099Q), Key Scientific and Technological projects of China (2004BA719A14) and Yunnan (2004NG12), CAS Projects (STZ-01-17; KSCX2- SW-216; KSCX1-SW-11), and National 863 Program (2003AA219142). ; The work was supported by grants from the National Natural Science Foundation of China (39500137), the Natural Science Foundation of Yunnan (95C0099Q), Key Scientific and Technological projects of China (2004BA719A14) and Yunnan (2004NG12), CAS Projects (STZ-01-17; KSCX2- SW-216; KSCX1-SW-11), and National 863 Program (2003AA219142). |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | The work was supported by grants from the National Natural Science Foundation of China (39500137), the Natural Science Foundation of Yunnan (95C0099Q), Key Scientific and Technological projects of China (2004BA719A14) and Yunnan (2004NG12), CAS Projects (STZ-01-17; KSCX2- SW-216; KSCX1-SW-11), and National 863 Program (2003AA219142). ; The work was supported by grants from the National Natural Science Foundation of China (39500137), the Natural Science Foundation of Yunnan (95C0099Q), Key Scientific and Technological projects of China (2004BA719A14) and Yunnan (2004NG12), CAS Projects (STZ-01-17; KSCX2- SW-216; KSCX1-SW-11), and National 863 Program (2003AA219142). ; The work was supported by grants from the National Natural Science Foundation of China (39500137), the Natural Science Foundation of Yunnan (95C0099Q), Key Scientific and Technological projects of China (2004BA719A14) and Yunnan (2004NG12), CAS Projects (STZ-01-17; KSCX2- SW-216; KSCX1-SW-11), and National 863 Program (2003AA219142). ; The work was supported by grants from the National Natural Science Foundation of China (39500137), the Natural Science Foundation of Yunnan (95C0099Q), Key Scientific and Technological projects of China (2004BA719A14) and Yunnan (2004NG12), CAS Projects (STZ-01-17; KSCX2- SW-216; KSCX1-SW-11), and National 863 Program (2003AA219142). |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/6434 |
| 专题 | 科研部门_分子免疫药理学（郑永唐） |
| 通讯作者 | zhengyt@mail.kiz.ac.cn |
| 作者单位 | 1.Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.The Graduate School of the Chinese Academy of Sciences, Beijing 100039, China |
| 推荐引用方式 GB/T 7714 | Liu GJ,Yang LM,Wang JH,et al. Immune Responses to Six Synthetic Peptides of Capsid Protein Immune Responses to Six Synthetic Peptides of Capsid Protein[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2005,2(4):289-293. |
| APA | Liu GJ.,Yang LM.,Wang JH.,Zhang GH.,Chen XM.,...&zhengyt@mail.kiz.ac.cn.(2005).Immune Responses to Six Synthetic Peptides of Capsid Protein Immune Responses to Six Synthetic Peptides of Capsid Protein.CELLULAR & MOLECULAR IMMUNOLOGY,2(4),289-293. |
| MLA | Liu GJ,et al."Immune Responses to Six Synthetic Peptides of Capsid Protein Immune Responses to Six Synthetic Peptides of Capsid Protein".CELLULAR & MOLECULAR IMMUNOLOGY 2.4(2005):289-293. |
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