Synthesis and Biological Evaluation of Andrographolide Derivatives as Potent Anti-HIV Agents

	Synthesis and Biological Evaluation of Andrographolide Derivatives as Potent Anti-HIV Agents
	Tang CL 1,2; Liu YJ 3,4; Wang B 1,5; Gu GL 1; Yang LM 3; Zheng YT 3; Qian H*1; Huang WL 1; qianhai24@163.com
	2012
发表期刊	ARCHIV DER PHARMAZIE
卷号	345 期号:8 页码:647-656
合作性质	其它
摘要	In an attempt to develop potent anti-HIV drugs, 20 andrographolide derivatives were designed, synthesized, and evaluated for their in vitro anti-HIV activity. The screening results revealed that five compounds showed potent anti-HIV activities with therapeutic indices (TI) above 10. The most promising compound 6f shows a significant TI close to 34.07, with the potency to be a new lead.
关键词	Andrographolide Derivatives Anti-hiv Synthesis
资助者	he work was supported by the Important National Science & Technology Specific Projects of China (No. 2009ZX09103-033 and 2009ZX09501-029), the National Basic Research Program of China (2009CB522306), the National Natural Science Foundation of China (No. 81172932), and the Fundamental Research Funds for the Central Universities of China (No. 2J10023). ; he work was supported by the Important National Science & Technology Specific Projects of China (No. 2009ZX09103-033 and 2009ZX09501-029), the National Basic Research Program of China (2009CB522306), the National Natural Science Foundation of China (No. 81172932), and the Fundamental Research Funds for the Central Universities of China (No. 2J10023). ; he work was supported by the Important National Science & Technology Specific Projects of China (No. 2009ZX09103-033 and 2009ZX09501-029), the National Basic Research Program of China (2009CB522306), the National Natural Science Foundation of China (No. 81172932), and the Fundamental Research Funds for the Central Universities of China (No. 2J10023). ; he work was supported by the Important National Science & Technology Specific Projects of China (No. 2009ZX09103-033 and 2009ZX09501-029), the National Basic Research Program of China (2009CB522306), the National Natural Science Foundation of China (No. 81172932), and the Fundamental Research Funds for the Central Universities of China (No. 2J10023).
收录类别	SCI
语种	英语
资助者	he work was supported by the Important National Science & Technology Specific Projects of China (No. 2009ZX09103-033 and 2009ZX09501-029), the National Basic Research Program of China (2009CB522306), the National Natural Science Foundation of China (No. 81172932), and the Fundamental Research Funds for the Central Universities of China (No. 2J10023). ; he work was supported by the Important National Science & Technology Specific Projects of China (No. 2009ZX09103-033 and 2009ZX09501-029), the National Basic Research Program of China (2009CB522306), the National Natural Science Foundation of China (No. 81172932), and the Fundamental Research Funds for the Central Universities of China (No. 2J10023). ; he work was supported by the Important National Science & Technology Specific Projects of China (No. 2009ZX09103-033 and 2009ZX09501-029), the National Basic Research Program of China (2009CB522306), the National Natural Science Foundation of China (No. 81172932), and the Fundamental Research Funds for the Central Universities of China (No. 2J10023). ; he work was supported by the Important National Science & Technology Specific Projects of China (No. 2009ZX09103-033 and 2009ZX09501-029), the National Basic Research Program of China (2009CB522306), the National Natural Science Foundation of China (No. 81172932), and the Fundamental Research Funds for the Central Universities of China (No. 2J10023).
WOS记录号	WOS:000307069200008
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7023
专题	科研部门_分子免疫药理学（郑永唐）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	qianhai24@163.com
作者单位	1.Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P . R. China 2.School of Medicine and Pharmaceutics, Jiangnan University, Wuxi, P . R. China 3.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, P . R. China 4.Graduate School of the Chinese Academy of Sciences, Beijing, P . R. China 5.Technology Center, Jiangsu Yabang Pharmaceutical Group, Changzhou, P . R. China
推荐引用方式 GB/T 7714	Tang CL,Liu YJ,Wang B,et al. Synthesis and Biological Evaluation of Andrographolide Derivatives as Potent Anti-HIV Agents[J]. ARCHIV DER PHARMAZIE,2012,345(8):647-656.
APA	Tang CL.,Liu YJ.,Wang B.,Gu GL.,Yang LM.,...&qianhai24@163.com.(2012).Synthesis and Biological Evaluation of Andrographolide Derivatives as Potent Anti-HIV Agents.ARCHIV DER PHARMAZIE,345(8),647-656.
MLA	Tang CL,et al."Synthesis and Biological Evaluation of Andrographolide Derivatives as Potent Anti-HIV Agents".ARCHIV DER PHARMAZIE 345.8(2012):647-656.

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