Decoding the phosphorylation code in Hedgehog signal  transduction

	Decoding the phosphorylation code in Hedgehog signal transduction
	Chen YB1; Jiang J2; ybchen@mail.kiz.ac.cn ; jin.jiang@utsouthwestern.edu
	2013
发表期刊	CELL RESEARCH
卷号	23 期号:2 页码:186-200
合作性质	其它
摘要	Hedgehog (Hh) signaling plays pivotal roles in embryonic development and adult tissue homeostasis, and its deregulation leads to numerous human disorders including cancer. Binding of Hh to Patched (Ptc), a twelve-transmembrane protein, alleviates its inhibition of Smoothened (Smo), a seven-transmembrane protein related to G-protein-coupled receptors (GPCRs), leading to Smo phosphorylation and activation. Smo acts through intracellular signaling complexes to convert the latent transcription factor Cubitus interruptus (Ci)/Gli from a truncated repressor to a full-length activator, leading to derepression/activation of Hh target genes. Increasing evidence suggests that phosphorylation participates in almost every step in the signal relay from Smo to Ci/Gli, and that differential phosphorylation of several key pathway components may be crucial for translating the Hh morphogen gradient into graded pathway activities. In this review, we focus on the multifaceted roles that phosphorylation plays in Hh signal transduction, and discuss the conservation and difference between Drosophila and mammalian Hh signaling mechanisms.
关键词	Hedgehog Smo Gli Signal Transduction Phosphorylation Development Cancer
资助者	Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW.
收录类别	SCI
语种	英语
资助者	Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW. ; Y Chen is supported by grants from the National Natural Science Foundation of China (31271579), National Key Basic Research Program of China (2013CB910900), American Heart Association postdoctoral fellowship (10POST3640046), Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH (GM067045 and GM061269), CPRIT (RP100561) and Welch foundation (I-1603), and is a Eugene McDermott Endowed Schol- ar of Biomedical Science at UTSW.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7354
专题	科研部门_肿瘤信号转导（陈勇彬）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	ybchen@mail.kiz.ac.cn; jin.jiang@utsouthwestern.edu
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kun- ming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming, Yunnan 650223, China 2.Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
推荐引用方式 GB/T 7714	Chen YB,Jiang J,ybchen@mail.kiz.ac.cn,et al. Decoding the phosphorylation code in Hedgehog signal transduction[J]. CELL RESEARCH,2013,23(2):186-200.
APA	Chen YB,Jiang J,ybchen@mail.kiz.ac.cn,&jin.jiang@utsouthwestern.edu.(2013).Decoding the phosphorylation code in Hedgehog signal transduction.CELL RESEARCH,23(2),186-200.
MLA	Chen YB*,et al."Decoding the phosphorylation code in Hedgehog signal transduction".CELL RESEARCH 23.2(2013):186-200.

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