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	Aging affects the direction selectivity of MT cells in rhesus monkeys
	Liang Z1; Yang Y1; Li GX1; Zhang J4; Wang YC1,2; Zhou YF*1,3; Leventhal AG1,2; zhouy@ustc.edu.cn
	2010
发表期刊	NEUROBIOLOGY OF AGING
卷号	31期号:5页码:863-873
合作性质	其它
摘要	The ability to accurately perceive the direction and speed of moving objects declines during normal aging. This is likely due to functional degradation of cortical neurons. Most neurons in the primate middle temporal area (MT) are direction-selective and their activity is closely linked to the perception of coherent motion. We investigated the mechanisms that underlie this age-related decline by comparing the proportions of direction-selective MT cells in old and young macaque monkeys, using in vivo single-cell recording techniques. Our results showed that the proportion of such cells was lower in old than in young monkeys. Moreover, one type of direction-sensitive cells, pattern cells, was especially sensitive to aging and was affected more severely than another class, component cells. We also found that direction selectivity was affected more severely in MT than in VI of senescent monkeys. Thus, the functional degradation of MT and VI cells may mediate perceptual decline in visual motion tasks in old primates
关键词	Aging Area Mt Degradation Direction Selectivity Monkey Pattern Cell
资助者	This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803).
收录类别	SCI
语种	英语
资助者	This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). ; This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7684
专题	科研部门_神经系统编码（胡新天）
通讯作者	zhouy@ustc.edu.cn
作者单位	1.Vision Research Laboratory, School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, PR China 2.Department of Neurobiology and Anatomy, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA 3.State key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Science, Beijing 100101, PR China 4.Laboratory of Primate Cognitive Neuroscience, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, Yunnan 650223, China
推荐引用方式 GB/T 7714	Liang Z,Yang Y,Li GX,et al. Aging affects the direction selectivity of MT cells in rhesus monkeys[J]. NEUROBIOLOGY OF AGING,2010,31(5):863-873.
APA	Liang Z.,Yang Y.,Li GX.,Zhang J.,Wang YC.,...&zhouy@ustc.edu.cn.(2010).Aging affects the direction selectivity of MT cells in rhesus monkeys.NEUROBIOLOGY OF AGING,31(5),863-873.
MLA	Liang Z,et al."Aging affects the direction selectivity of MT cells in rhesus monkeys".NEUROBIOLOGY OF AGING 31.5(2010):863-873.

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2013092602.pdf（607KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文

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