Evolutionary perspective on hepatitis B virus with an expanded sampling strategy

	Evolutionary perspective on hepatitis B virus with an expanded sampling strategy
	He JD 1; Gao JM 1; Shen T 1; Murphy RW 2,3; Yan XM*1; yxmin08@163.com
	2013
发表期刊	VIRUS RESEARCH
卷号	178 期号:2 页码:525-529
合作性质	其它
摘要	To investigate the role hepatitis Be antigen (HBeAg) plays in the evolution of hepatitis B virus (HBV), we sequenced the basic core promoter (BCP) and precore (preC) regions of 348 clones total from ten HBV Chinese patients. Eleven mutations were more frequent in HBeAg-negative patients than in HBeAg-positive patients. Further, the sequencing of dozens of variants was found to be necessary to obtain mutation profiles. Phylogenetic and median-joining network analyses suggested that variants from each patient had a single common ancestor (monophyly). Higher haplotype and nucleotide diversities were identified in HBeAg-negative"patients. Analysis of dNIdS suggested that viruses experiencing a stronger immune response had lower haplotype diversity. Because HBeAg seroconversion was associated with viral diversity it served as an indicator of HBV evolution. Significantly, this study indicated a larger sampling of variants from each patient was required to understand effectively the properties of HBV.
关键词	Evolution Hbeag Sampling Strategy
资助者	This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada.
收录类别	SCI
语种	英语
资助者	This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada. ; This work was supported by the Natural Science Foundation of Yunnan Province (Grant no. 200300172), in part by special fund of Science and Technology Department of Yunnan Province in asso- ciation with Kunming Medical College (2012FB097), in part by Foundation of Yunnan Provincial Bureau of Health (2010NS004), in part by National Natural Science Foundation of China (No. 81160352), in part by a Visiting Professorship for Senior Interna- tional Scientists from the Chinese Academy of Sciences, and in part by Discovery Grant 3148 from the Natural Sciences and Engineering Research Council of Canada.
WOS记录号	WOS:000329266300043
引用统计
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7796
专题	科研部门_分子进化与基因组多样性（张亚平）遗传资源与进化国家重点实验室
通讯作者	yxmin08@163.com
作者单位	1.Institute of Clinical and Basic Medical Sciences, Center of Clinical Molecular Biology, Key Laboratory for Birth Defects and Genetic Diseases, First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 3.Centre for Biodiversity and Conservation Biology, Royal Ontario Museum, Toronto, Canada
推荐引用方式 GB/T 7714	He JD,Gao JM,Shen T,et al. Evolutionary perspective on hepatitis B virus with an expanded sampling strategy[J]. VIRUS RESEARCH,2013,178(2):525-529.
APA	He JD,Gao JM,Shen T,Murphy RW,Yan XM*,&yxmin08@163.com.(2013).Evolutionary perspective on hepatitis B virus with an expanded sampling strategy.VIRUS RESEARCH,178(2),525-529.
MLA	He JD,et al."Evolutionary perspective on hepatitis B virus with an expanded sampling strategy".VIRUS RESEARCH 178.2(2013):525-529.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2014021003.pdf（745KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文