Trefoil factor 1 gene alternations and expression in colorectal carcinomas

	Trefoil factor 1 gene alternations and expression in colorectal carcinomas
	Huang YG 1,2; Li YF 2; Pan BL 3; Wang LP 4; Zhang Y1 ; Lee WH 1; Zhang Y*1; zhangy@mail.kiz.ac.cn
	2013
发表期刊	TUMORI
卷号	99 期号:6 页码:702-707
合作性质	其它
摘要	Aims and backgroound. Aberrant expression of the trefoil factor family (TFF) has been recognized to be involved in the development and/or progression of various solid tumors. Increased trefoil factor 1 (TFF1) expression is found associated with tumor progression in Some tumors, and TFF1 missense mutations have been:detected in gastric cancer. The aim of the study-was to analyze TFF1 alternations and expression in colorectal carcinoma and their correlation with cancer progression and pathological aspects. Methods. TFF1 mutations were detected in colorectal carcinomas by DNA sequencing. TFF1 mRNA and protein levels in subsets of the primary tumors were determined using quantitative reverse transcription polymerase chain reaction and immunohistochemistry analyses.. The serum level of TFF1 was also detected by enzyme-linked immunosorbent assay for patients with colorectal carcinoma. Results. Five variants were detected in the 5'-untranslation region and intron 1 of TFF1. TFF1 expression was increased in colorectal carcinoma compared to paired distal colonic mucosa. Immunohistochemistry in primary colorectal carcinoma showed no significant differences in tumor TFF1 levels with respect to clinicopathological parameters such as the patient's sex, cancer differentiation, stage and lymph node metastasis. However, serum TFF1 levels were significantly elevated in patients with colorectal carcinoma compared to healthy individuals. Conclusions. The results' indicate that TFF1, missense mutations seem to be a rare event in colorectal carcinogenesis. Serum, TFF1 may be a potential useful marker for patients with colorectal carcinoma.
关键词	Cancer Progress Colorectal Carcinoma Trefoil Factor 1
收录类别	SCI
语种	英语
WOS记录号	WOS:000330925900010
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7815
专题	科研部门_生物毒素与人类疾病（张云）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	zhangy@mail.kiz.ac.cn
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, 650223, China 2.Tumor institue of Yunnan Province, The 3 rd Affiliated Hospital of Kunming 3.Department of Clinical Laboratory, The 1 st Hospital of Yuxi, Yunnan Province 4.Department of Pathology, Yan-an Hospital of Kunming, Kunming, China
推荐引用方式 GB/T 7714	Huang YG,Li YF,Pan BL,et al. Trefoil factor 1 gene alternations and expression in colorectal carcinomas[J]. TUMORI,2013,99(6):702-707.
APA	Huang YG.,Li YF.,Pan BL.,Wang LP.,Zhang Y.,...&zhangy@mail.kiz.ac.cn.(2013).Trefoil factor 1 gene alternations and expression in colorectal carcinomas.TUMORI,99(6),702-707.
MLA	Huang YG,et al."Trefoil factor 1 gene alternations and expression in colorectal carcinomas".TUMORI 99.6(2013):702-707.

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