A Linguistically Informed Autosomal STR Survey of Human Populations Residing in the Greater Himalayan Region

KIZ OpenIR > 科研部门 > 比较基因组学（宿兵）

	A Linguistically Informed Autosomal STR Survey of Human Populations Residing in the Greater Himalayan Region
	Kraaijenbrink T 1; van der Gaag KJ 1; Zuniga SB 1; Xue YL 2; Carvalho-Silva DR 2; Tyler-Smith C 2; Jobling MA 3; Barbujani G 9; Su B4 ; Shi H 4; de Knijff P*1; knijff@lumc.nl
	2014
发表期刊	PLOS ONE
卷号	9 期号:3 页码:e91534
合作性质	其它
摘要	The greater Himalayan region demarcates two of the most prominent linguistic phyla in Asia: Tibeto-Burman and Indo-European. Previous genetic surveys, mainly using Y-chromosome polymorphisms and/or mitochondrial DNA polymorphisms suggested a substantially reduced geneflow between populations belonging to these two phyla. These studies, however, have mainly focussed on populations residing far to the north and/or south of this mountain range, and have not been able to study geneflow patterns within the greater Himalayan region itself. We now report a detailed, linguistically informed, genetic survey of Tibeto-Burman and Indo-European speakers from the Himalayan countries Nepal and Bhutan based on autosomal microsatellite markers and compare these populations with surrounding regions. The genetic differentiation between populations within the Himalayas seems to be much higher than between populations in the neighbouring countries. We also observe a remarkable genetic differentiation between the Tibeto-Burman speaking populations on the one hand and Indo-European speaking populations on the other, suggesting that language and geography have played an equally large role in defining the genetic composition of present-day populations within the Himalayas.
资助者	This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576).
收录类别	SCI
语种	英语
资助者	This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576). ; This work, as part of the European Science Foundation EUROCORES Programme OMLL, was supported by funds from NWO (Netherlands Organisation for Scientific Research, grant no. 231-70-001), the Arts and Humanities Research Board of Great Britain (grant no. AN/9585/APN15314) and the EC Sixth Framework Programme (Contract no. ERAS-CT-2003-980409). YX and CTS are supported by The Wellcome Trust (WT 098051), and MAJ by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (WT 087576).
WOS记录号	WOS:000332839300135
引用统计
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/8119
专题	科研部门_比较基因组学（宿兵）遗传资源与进化国家重点实验室
通讯作者	knijff@lumc.nl
作者单位	1.MGC Department of Human and Clinical Genetics, Leiden University Medical Centre, Leiden, the Netherlands 2.The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom 3.Department of Genetics, University of Leicester, Leicester, United Kingdom 4.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology and Kunming Primate Research Centre, Chinese Academy of Sciences, Kunming, Yunnan, PR Chin 5.Human Genetics Centre, Yunnan University, Kunming, Yunnan, PR China 6.National DNA Analysis Center, Central Forensic Science Laboratory, Kolkata, India 7.Himalayan Languages Project, Institut fu ¨r Sprachwissenschaft, University of Bern, Bern, Switzerland 8.Centre for Nepal and Asian Studies, Tribhuvan University, Kirtipur, Nepal 9.Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy
推荐引用方式 GB/T 7714	Kraaijenbrink T,van der Gaag KJ,Zuniga SB,et al. A Linguistically Informed Autosomal STR Survey of Human Populations Residing in the Greater Himalayan Region[J]. PLOS ONE,2014,9(3):e91534.
APA	Kraaijenbrink T.,van der Gaag KJ.,Zuniga SB.,Xue YL.,Carvalho-Silva DR.,...&knijff@lumc.nl.(2014).A Linguistically Informed Autosomal STR Survey of Human Populations Residing in the Greater Himalayan Region.PLOS ONE,9(3),e91534.
MLA	Kraaijenbrink T,et al."A Linguistically Informed Autosomal STR Survey of Human Populations Residing in the Greater Himalayan Region".PLOS ONE 9.3(2014):e91534.

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