| The Recombinant Maize Ribosome-Inactivating Protein Transiently Reduces Viral Load in SHIV89.6 Infected Chinese Rhesus Macaques | |
| Wang RR1; Au KY2; Zheng HY1; Gao LM3; Zhang X1; Luo RH1; Law SKY2; Mak ANS2; Wong KB2; Zhang MX1; Pang W1; Zhang GH1; Shaw PC*2; Zheng YT*1; pcshaw@cuhk.edu.hk; zhengyt@mail.kiz.ac.cn | |
| 2015 | |
| 发表期刊 | TOXINS
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| 卷号 | 7期号:1页码:156-169 |
| 合作性质 | 其它 |
| 摘要 | Ribosome inactivating proteins (RIPs) inhibit protein synthesis by depurinating the large ribosomal RNA and some are found to possess anti-human immunodeficiency virus (HIV) activity. Maize ribosome inactivating protein (RIP) has an internal inactivation loop which is proteolytically removed for full catalytic activity. Here, we showed that the recombinant active maize RIP protected chimeric simian-human immunodeficiency virus (SHIV) 89.6-infected macaque peripheral blood mononuclear cells from lysis ex vivo and transiently reduced plasma viral load in SHIV89.6-infected rhesus macaque model. No evidence of immune dysregulation and other obvious side-effects was found in the treated macaques. Our work demonstrates the potential development of maize RIP as an anti-HIV agent without impeding systemic immune functions. |
| 关键词 | Maize Rip Anti-hiv Animal Model Viral Load |
| 资助者 | Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). ; Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2013ZX10001-002; 2014ZX10005-002), the National Basic Research Program of China (2012CBA01305), NSFC (81273251; 81172876), Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan and the Knowledge Innovation Program of CAS (KJZD-EW-L10-02). Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/8268 |
| 专题 | 科研部门_分子免疫药理学（郑永唐） 科研部门_动物模型与人类重大疾病机理重点实验室 |
| 通讯作者 | pcshaw@cuhk.edu.hk; zhengyt@mail.kiz.ac.cn |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 2.Center for Protein Science and Crystallography, School of Life Sciences, the Chinese University of Hong Kong, Shatin N.T. 999077, Hong Kong, China 3.Division of HIV/AIDS and STI Control, Yuxi Centers for Disease Control and Prevention, Yuxi 653100, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Wang RR,Au KY,Zheng HY,et al. The Recombinant Maize Ribosome-Inactivating Protein Transiently Reduces Viral Load in SHIV89.6 Infected Chinese Rhesus Macaques[J]. TOXINS,2015,7(1):156-169. |
| APA | Wang RR.,Au KY.,Zheng HY.,Gao LM.,Zhang X.,...&zhengyt@mail.kiz.ac.cn.(2015).The Recombinant Maize Ribosome-Inactivating Protein Transiently Reduces Viral Load in SHIV89.6 Infected Chinese Rhesus Macaques.TOXINS,7(1),156-169. |
| MLA | Wang RR,et al."The Recombinant Maize Ribosome-Inactivating Protein Transiently Reduces Viral Load in SHIV89.6 Infected Chinese Rhesus Macaques".TOXINS 7.1(2015):156-169. |
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