KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2

	KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2
	Jia L 1,2,3; Zhou Z 1; Liang H 1; Wu J 1,3,4; Shi P1 ; Li F 1; Wang Z 1; Wang C 1,3,5; Chen W 6; Zhang H 1; Wang Y 6; Liu R 1; Feng J7; Chen C1
	2016
发表期刊	ONCOGENE
卷号	35 期号:16 页码:2040-2051
合作性质	其它
摘要	The Kruppel-like factor 5 (KLF5) transcription factor is highly expressed in high-grade and basal-like breast cancers. However, the mechanism by which KLF5 promotes cell migration and invasion is still not completely understood. In this study, we demonstrate that TNFAIP2, a tumor necrosis factor-alpha (TNF alpha)-induced gene, is a direct KLF5 target gene. The expression of TNFAIP2 is highly correlated with the expression of KLF5 in breast cancers. The manipulation of KLF5 expression positively alters TNFAIP2 expression levels. KLF5 directly binds to the TNFAIP2 gene promoter and activates its transcription. Functionally, KLF5 promotes cancer cell proliferation, migration and invasion in part through TNFAIP2. TNFAIP2 interacts with the two small GTPases Rac1 and Cdc42, thereby increasing their activities to change actin cytoskeleton and cell morphology. These findings collectively suggest that TNFAIP2 is a direct KLF5 target gene, and both KLF5 and TNFAIP2 promote breast cancer cell proliferation, migration and invasion through Rac1 and Cdc42.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/9418
专题	科研部门_进化与功能基因组学（施鹏）科研部门_动物模型与人类重大疾病机理重点实验室遗传资源与进化国家重点实验室科研部门_肿瘤生物学（陈策实）
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Department of Biology, Yuxi Normal University, Yuxi, China 3.University of the Chinese Academy of Sciences, Beijing, China 4.Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China 5.Department of Pathology, First Affiliated Hospital of Kunming Medical University, Kunming, China 6.Cancer Hospital, Kunming Medical University, Kunming, China 7.Department of Laboratory Medicine & Central Laboratory, Southern Medical University-Affiliated Fengxian Hospital, Shanghai, China 8.Southern Med Univ, Affiliated Fengxian Hosp, Cent Lab, Shanghai 201499, Peoples R China
推荐引用方式 GB/T 7714	Jia L,Zhou Z,Liang H,et al. KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2[J]. ONCOGENE,2016,35(16):2040-2051.
APA	Jia L.,Zhou Z.,Liang H.,Wu J.,Shi P.,...&Chen C*.(2016).KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2.ONCOGENE,35(16),2040-2051.
MLA	Jia L,et al."KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2".ONCOGENE 35.16(2016):2040-2051.

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