| A mixed community of actinomycetes produce multiple antibiotics for the fungus farming ant Acromyrmex octospinosus | |
| Barke J1; Seipke RF1; Gruschow S2; Heavens D3; Drou N3; Bibb MJ4; Goss RJM2; Yu DW1,5; Hutchings MI*1,6; m.hutchings@uea.ac.uk | |
| 2010 | |
| 发表期刊 | BMC BIOLOGY
 |
| 卷号 | 8期号:X页码:e109 |
| 合作性质 | 其它 |
| 摘要 | Background: Attine ants live in an intensely studied tripartite mutualism with the fungus Leucoagaricus gongylophorus, which provides food to the ants, and with antibiotic-producing actinomycete bacteria. One hypothesis suggests that bacteria from the genus Pseudonocardia are the sole, co-evolved mutualists of attine ants and are transmitted vertically by the queens. A recent study identified a Pseudonocardia-produced antifungal, named dentigerumycin, associated with the lower attine Apterostigma dentigerum consistent with the idea that co-evolved Pseudonocardia make novel antibiotics. An alternative possibility is that attine ants sample actinomycete bacteria from the soil, selecting and maintaining those species that make useful antibiotics. Consistent with this idea, a Streptomyces species associated with the higher attine Acromyrmex octospinosus was recently shown to produce the well-known antifungal candicidin. Candicidin production is widespread in environmental isolates of Streptomyces, so this could either be an environmental contaminant or evidence of recruitment of useful actinomycetes from the environment. It should be noted that the two possibilities for actinomycete acquisition are not necessarily mutually exclusive. Results: In order to test these possibilities we isolated bacteria from a geographically distinct population of A. octospinosus and identified a candicidin-producing Streptomyces species, which suggests that they are common mutualists of attine ants, most probably recruited from the environment. We also identified a Pseudonocardia species in the same ant colony that produces an unusual polyene antifungal, providing evidence for co-evolution of Pseudonocardia with A. octospinosus. Conclusions: Our results show that a combination of co-evolution and environmental sampling results in the diversity of actinomycete symbionts and antibiotics associated with attine ants. |
| 资助者 | This work was supported by a UEA-funded PhD studentship (JB) and an MRC Milstein award, G0801721 (MIH, RJMG and DY). MIH is a Research Councils UK Fellow. DY also received support from the Yunnan provincial government (20080A001) and the Chinese Academy of Sciences (0902281081). Genome sequencing was carried out at The Genome Analysis Centre under a Capacity and Capability Challenge project with MIH and MJB. ; This work was supported by a UEA-funded PhD studentship (JB) and an MRC Milstein award, G0801721 (MIH, RJMG and DY). MIH is a Research Councils UK Fellow. DY also received support from the Yunnan provincial government (20080A001) and the Chinese Academy of Sciences (0902281081). Genome sequencing was carried out at The Genome Analysis Centre under a Capacity and Capability Challenge project with MIH and MJB. ; This work was supported by a UEA-funded PhD studentship (JB) and an MRC Milstein award, G0801721 (MIH, RJMG and DY). MIH is a Research Councils UK Fellow. DY also received support from the Yunnan provincial government (20080A001) and the Chinese Academy of Sciences (0902281081). Genome sequencing was carried out at The Genome Analysis Centre under a Capacity and Capability Challenge project with MIH and MJB. ; This work was supported by a UEA-funded PhD studentship (JB) and an MRC Milstein award, G0801721 (MIH, RJMG and DY). MIH is a Research Councils UK Fellow. DY also received support from the Yunnan provincial government (20080A001) and the Chinese Academy of Sciences (0902281081). Genome sequencing was carried out at The Genome Analysis Centre under a Capacity and Capability Challenge project with MIH and MJB. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This work was supported by a UEA-funded PhD studentship (JB) and an MRC Milstein award, G0801721 (MIH, RJMG and DY). MIH is a Research Councils UK Fellow. DY also received support from the Yunnan provincial government (20080A001) and the Chinese Academy of Sciences (0902281081). Genome sequencing was carried out at The Genome Analysis Centre under a Capacity and Capability Challenge project with MIH and MJB. ; This work was supported by a UEA-funded PhD studentship (JB) and an MRC Milstein award, G0801721 (MIH, RJMG and DY). MIH is a Research Councils UK Fellow. DY also received support from the Yunnan provincial government (20080A001) and the Chinese Academy of Sciences (0902281081). Genome sequencing was carried out at The Genome Analysis Centre under a Capacity and Capability Challenge project with MIH and MJB. ; This work was supported by a UEA-funded PhD studentship (JB) and an MRC Milstein award, G0801721 (MIH, RJMG and DY). MIH is a Research Councils UK Fellow. DY also received support from the Yunnan provincial government (20080A001) and the Chinese Academy of Sciences (0902281081). Genome sequencing was carried out at The Genome Analysis Centre under a Capacity and Capability Challenge project with MIH and MJB. ; This work was supported by a UEA-funded PhD studentship (JB) and an MRC Milstein award, G0801721 (MIH, RJMG and DY). MIH is a Research Councils UK Fellow. DY also received support from the Yunnan provincial government (20080A001) and the Chinese Academy of Sciences (0902281081). Genome sequencing was carried out at The Genome Analysis Centre under a Capacity and Capability Challenge project with MIH and MJB. |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/353002/6539 |
| 专题 | 科研部门_生态学与环境保护中心（俞维理） 遗传资源与进化国家重点实验室 |
| 通讯作者 | m.hutchings@uea.ac.uk |
| 作者单位 | 1.School of Biological Sciences, University of East Anglia, Norwich, Norwich Research Park, NR4 7TJ, UK. 2.School of Chemistry, University of East Anglia, Barke et al. BMC Biology 2010, 8:109 http://www.biomedcentral.com/1741-7007/8/109 Page 9 of 10 Norwich, Norwich Research Park, NR4 7TJ, UK. 3.The Genome Analysis Centre, Norwich, Norwich Research Park, NR4 7UH, UK 4.Department of Molecular Microbiology, John Innes Centre, Norwich, Norwich Research Park, NR4 7UH, UK 5.State Key Laboratory of Genetic Resources, and Evolution, Ecology, Conservation and Environment Center (ECEC), Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 6.School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, Norwich Research Park, NR4 7TJ, UK. |
| 推荐引用方式 GB/T 7714 | Barke J,Seipke RF,Gruschow S,et al. A mixed community of actinomycetes produce multiple antibiotics for the fungus farming ant Acromyrmex octospinosus[J]. BMC BIOLOGY,2010,8(X):e109. |
| APA | Barke J.,Seipke RF.,Gruschow S.,Heavens D.,Drou N.,...&m.hutchings@uea.ac.uk.(2010).A mixed community of actinomycetes produce multiple antibiotics for the fungus farming ant Acromyrmex octospinosus.BMC BIOLOGY,8(X),e109. |
| MLA | Barke J,et al."A mixed community of actinomycetes produce multiple antibiotics for the fungus farming ant Acromyrmex octospinosus".BMC BIOLOGY 8.X(2010):e109. |
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