Synthesis and Preliminary Anti-HIV Activities of Andrographolide Derivatives

	Synthesis and Preliminary Anti-HIV Activities of Andrographolide Derivatives
	Wang B 1; Ge LA 2; Huang WL1; Zhang HB 1; Qian H 1; Li J3; Zheng YT 4; ydhuangwenlong@126.com ; lij@scut.edu.cn
	2010
发表期刊	MEDICINAL CHEMISTRY
卷号	6 期号:4 页码:252-258
合作性质	其它
摘要	Recent studies indicated that andrographolide was a potential anti-HIV therapeutic agent. In the paper, the synthesis of a series of andrographolide derivatives was described and their anti-HIV activities were evaluated in vitro. As compared with TI, compounds 5c, 5d and 5i showed moderate inhibitory activities on the cytopathic effect with TI above 10. Among the derivatives, compound 5i was the best one with TI > 51
关键词	Andrographolide Anti-hiv Derivatives Synthesis
资助者	The work was supported by the National Natural Science Fundation of China (No. 30772647 and 81001363) and the Fundamental Research Funds for the Central Universities of China (No. 2009ZM0084). ; The work was supported by the National Natural Science Fundation of China (No. 30772647 and 81001363) and the Fundamental Research Funds for the Central Universities of China (No. 2009ZM0084). ; The work was supported by the National Natural Science Fundation of China (No. 30772647 and 81001363) and the Fundamental Research Funds for the Central Universities of China (No. 2009ZM0084). ; The work was supported by the National Natural Science Fundation of China (No. 30772647 and 81001363) and the Fundamental Research Funds for the Central Universities of China (No. 2009ZM0084).
收录类别	SCI
语种	英语
资助者	The work was supported by the National Natural Science Fundation of China (No. 30772647 and 81001363) and the Fundamental Research Funds for the Central Universities of China (No. 2009ZM0084). ; The work was supported by the National Natural Science Fundation of China (No. 30772647 and 81001363) and the Fundamental Research Funds for the Central Universities of China (No. 2009ZM0084). ; The work was supported by the National Natural Science Fundation of China (No. 30772647 and 81001363) and the Fundamental Research Funds for the Central Universities of China (No. 2009ZM0084). ; The work was supported by the National Natural Science Fundation of China (No. 30772647 and 81001363) and the Fundamental Research Funds for the Central Universities of China (No. 2009ZM0084).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/353002/6616
专题	科研部门_分子免疫药理学（郑永唐）
通讯作者	ydhuangwenlong@126.com; lij@scut.edu.cn
作者单位	1.Center of Drug Discovery, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China 2.Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China 3.School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China 4.Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
推荐引用方式 GB/T 7714	Wang B,Ge LA,Huang WL*,et al. Synthesis and Preliminary Anti-HIV Activities of Andrographolide Derivatives[J]. MEDICINAL CHEMISTRY,2010,6(4):252-258.
APA	Wang B.,Ge LA.,Huang WL*.,Zhang HB.,Qian H.,...&lij@scut.edu.cn.(2010).Synthesis and Preliminary Anti-HIV Activities of Andrographolide Derivatives.MEDICINAL CHEMISTRY,6(4),252-258.
MLA	Wang B,et al."Synthesis and Preliminary Anti-HIV Activities of Andrographolide Derivatives".MEDICINAL CHEMISTRY 6.4(2010):252-258.

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