Effects of beta-adrenergic antagonist, propranolol on spatial memory and exploratory behavior in mice

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	Effects of beta-adrenergic antagonist, propranolol on spatial memory and exploratory behavior in mice
	Sun HY 1; Mao Y 1,2; Wang JH 1; Ma YY*1,3; yuanma0716@vip.sina.com
	2011
发表期刊	NEUROSCIENCE LETTERS
卷号	498 期号:2 页码:133-137
合作性质	其它
摘要	The beta-adrenergic system has been suggested to be involved in novelty detection and memory modulation. The present study aimed to investigate the role of beta-adrenergic receptors on novelty-based spatial recognition memory and exploratory behavior in mice using Y-maze test and open-field respectively. Mice were injected with three doses of beta-adrenergic receptor antagonist, propranolol (2, 10 and 20 mg/kg) or saline at three different time points (15 min prior to training, immediately after training and 15 min before test). The results showed that higher doses of propranolol (10 and 20 mg/kg) given before the training trial impaired spatial recognition memory while those injected at other two time points did not. A detailed analysis of exploratory behavior in open-field showed that lower dose (2 mg/kg) of propranolol reduced exploratory behavior of mice. Our findings indicate that higher dose of propranolol can impair acquisition of spatial information in the Y-maze without altering locomotion, suggesting that the beta-adrenergic system may be involved in modulating memory processes at the time of learning.
关键词	Propranolol Y-maze Mice Spatial Memory Acquisition
资助者	This study was supported by National Science Foundation of China (NSFC 30770700), the Major State Basic Research of China (NO2003CB716600). ; This study was supported by National Science Foundation of China (NSFC 30770700), the Major State Basic Research of China (NO2003CB716600). ; This study was supported by National Science Foundation of China (NSFC 30770700), the Major State Basic Research of China (NO2003CB716600). ; This study was supported by National Science Foundation of China (NSFC 30770700), the Major State Basic Research of China (NO2003CB716600).
收录类别	SCI
语种	英语
资助者	This study was supported by National Science Foundation of China (NSFC 30770700), the Major State Basic Research of China (NO2003CB716600). ; This study was supported by National Science Foundation of China (NSFC 30770700), the Major State Basic Research of China (NO2003CB716600). ; This study was supported by National Science Foundation of China (NSFC 30770700), the Major State Basic Research of China (NO2003CB716600). ; This study was supported by National Science Foundation of China (NSFC 30770700), the Major State Basic Research of China (NO2003CB716600).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/353002/6636
专题	认知障碍病理学科研部门_神经系统编码（胡新天）
通讯作者	yuanma0716@vip.sina.com
作者单位	1.State Key Laboratory of Brain and Cognitive Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, PR China 2.Graduate University of Chinese Academy of Sciences, Beijing 100049, PR China 3.State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, PR China
推荐引用方式 GB/T 7714	Sun HY,Mao Y,Wang JH,et al. Effects of beta-adrenergic antagonist, propranolol on spatial memory and exploratory behavior in mice[J]. NEUROSCIENCE LETTERS,2011,498(2):133-137.
APA	Sun HY,Mao Y,Wang JH,Ma YY*,&yuanma0716@vip.sina.com.(2011).Effects of beta-adrenergic antagonist, propranolol on spatial memory and exploratory behavior in mice.NEUROSCIENCE LETTERS,498(2),133-137.
MLA	Sun HY,et al."Effects of beta-adrenergic antagonist, propranolol on spatial memory and exploratory behavior in mice".NEUROSCIENCE LETTERS 498.2(2011):133-137.

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