Maternal separation produces lasting changes in cortisol and behavior in rhesus monkeys

	Maternal separation produces lasting changes in cortisol and behavior in rhesus monkeys
	Feng XL 1,2,3; Wang LN 1,2,3; Yang SC 1,2; Qin DD 1,2,3; Wang JH 1,2; Li CL 1,2,3; Lv LB 2,4; Ma YY1,2,5; Hu XT1,2,5; yuanma0716@vip.sina.com ; xthu@mail.kiz.ac.cn
	2011
发表期刊	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷号	108 期号:34 页码:14312-14317
产权排序	We thank the radioimmuno-laboratory of the sec- ond affiliated hospital of Kunming Medical College for technical assis- tance. This study was funded by the National Science Foundation of China (NSFC 30770700, 30670669, 30870825, 30530270, 31070963, and 31070965), the 973 program (2007CB947703 and 2011CB707800), the Key Program of the Chinese Academy of Sciences, China (KSCX2-EW-J-23, KSCX2-YW-R-261, and KSCX2-EW-R-11), the West Light Foundation of the Chinese Academy of Sciences (0902351081), the National Natural Science Foundation of China (30921064), and the project sponsored by Yunnan Development and Reform Commission (2009-1988).
合作性质	其它
摘要	Maternal separation (MS), which can lead to hypothalamic pituitary adrenal axis dysfunction and behavioral abnormalities in rhesus monkeys, is frequently used to model early adversity. Whether this deleterious effect on monkeys is reversible by later experience is unknown. In this study, we assessed the basal hair cortisol in rhesus monkeys after 1.5 and 3 y of normal social life following an early separation. These results showed that peer-reared monkeys had significantly lower basal hair cortisol levels than the mother-reared monkeys at both years examined. The plasma cortisol was assessed in the monkeys after 1.5 y of normal social life, and the results indicated that the peak in the peer-reared cortisol response to acute stressors was substantially delayed. In addition, after 3 y of normal social life, abnormal behavioral patterns were identified in the peer-reared monkeys. They showed decreases in locomotion and initiated sitting together, as well as increases in stereotypical behaviors compared with the mother-reared monkeys. These results demonstrate that the deleterious effects of MS on rhesus monkeys cannot be compensated by a later normal social life, suggesting that the effects of MS are long-lasting and that the maternal-separated rhesus monkeys are a good animal model to study early adversity and to investigate the development of psychiatric disorders induced by exposure to early adversity.
关键词	Time Profile Unbound Fraction Of Cortisol Activity Repetitive Action Social Affiliative Behavior
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/353002/6759
专题	中国科学院昆明灵长类研究中心认知障碍病理学科研部门_神经系统编码（胡新天）
通讯作者	yuanma0716@vip.sina.com; xthu@mail.kiz.ac.cn
作者单位	1.State Key Laboratory of Brain and Cognitive Science 2.Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, Yunnan 650223, People’s Republic of China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100049, People’s Republic of China 4.Kunming Primate Research Center of the Chinese Academy of Sciences, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, Yunnan 650223, People’s Republic of China 5.Institute of Biophysics, the Chinese Academy of Sciences, Beijing 100101, People’s Republic of China
推荐引用方式 GB/T 7714	Feng XL,Wang LN,Yang SC,et al. Maternal separation produces lasting changes in cortisol and behavior in rhesus monkeys[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2011,108(34):14312-14317.
APA	Feng XL.,Wang LN.,Yang SC.,Qin DD.,Wang JH.,...&xthu@mail.kiz.ac.cn.(2011).Maternal separation produces lasting changes in cortisol and behavior in rhesus monkeys.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,108(34),14312-14317.
MLA	Feng XL,et al."Maternal separation produces lasting changes in cortisol and behavior in rhesus monkeys".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108.34(2011):14312-14317.

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