Expression of adhesion molecules and mucins in human and rhesus macaque gastrointestinal epithelial cells

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	Expression of adhesion molecules and mucins in human and rhesus macaque gastrointestinal epithelial cells
	Zhang HY 1,2,3; Chang H 1,2; Fan XN 1; Zhang KD 1,2; Yu L 4; Cao Y*1; caoy@mail.kiz.ac.cn
	2011
发表期刊	HISTOLOGY AND HISTOPATHOLOGY
卷号	26 期号:11 页码:1405-1413
合作性质	其它
摘要	Epithelial junctions and mucins play key roles in the gastrointestinal mucosal barrier, and their alterations are associated with numerous diseases, including carcinomas. The systematic expression of adhesion molecules and mucins in normal and malignant human gastrointestinal cells was investigated in this study. In normal human gastrointestinal cells, zonula occludens-1 (ZO-1), alpha-catenin, beta-catenin, gamma-catenin and desmoglein-2 (DSG2) were located in the cytoplasmic membranes, whereas symplekin stained in the nuclei. ZO-1, the three catenins, and DSG2 were observed in the gastric and colorectal carcinomas with reduced and heterogeneous expression and with abnormal distribution. Symplekin was detected in the nuclei of tumor cells in most tumors but not observed in some others. The immunohistochemical results for ZO-1 and symplekin on the tissues were consistent with the data for the cultured cells obtained by immunocytochemical staining and Western blot analysis. MUC1 was not stained in the normal gastrointestinal cells without periodate oxidation, but it was strongly labeled in the malignant gastrointestinal cells. MUC2 was detected in the normal and malignant gastrointestinal cells without the periodate treatment. These findings indicate that alterations in the expression of the epithelial junctions and mucins are associated with the malignant transformation of gastrointestinal cells. In addition, the gastrointestinal epithelial cells of rhesus macaques expressed these adhesion molecules and mucins, as did the human cells, suggesting that the rhesus monkey is a suitable experimental animal model for research on adhesion molecules and mucins.
关键词	Adhesion Molecule Mucin Gastrointestinal Epithelium Carcinoma Rhesus Macaque
资助者	This work was supported by grants from the National Natural Science Foundation of China (No. 30800407) and the Chinese Academy of Sciences (KSCX2-YW-R-092). ; This work was supported by grants from the National Natural Science Foundation of China (No. 30800407) and the Chinese Academy of Sciences (KSCX2-YW-R-092). ; This work was supported by grants from the National Natural Science Foundation of China (No. 30800407) and the Chinese Academy of Sciences (KSCX2-YW-R-092). ; This work was supported by grants from the National Natural Science Foundation of China (No. 30800407) and the Chinese Academy of Sciences (KSCX2-YW-R-092).
收录类别	SCI
语种	英语
资助者	This work was supported by grants from the National Natural Science Foundation of China (No. 30800407) and the Chinese Academy of Sciences (KSCX2-YW-R-092). ; This work was supported by grants from the National Natural Science Foundation of China (No. 30800407) and the Chinese Academy of Sciences (KSCX2-YW-R-092). ; This work was supported by grants from the National Natural Science Foundation of China (No. 30800407) and the Chinese Academy of Sciences (KSCX2-YW-R-092). ; This work was supported by grants from the National Natural Science Foundation of China (No. 30800407) and the Chinese Academy of Sciences (KSCX2-YW-R-092).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/353002/6819
专题	分子病理学科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	caoy@mail.kiz.ac.cn
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of CAS and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Graduate University of the Chinese Academy of Sciences, Beijing, China 3.Department of Gastroenterology, Kunming First People’s Hospital, Kunming, China 4.Department of Pathology, Kunming First People’s Hospital, Kunming, China
推荐引用方式 GB/T 7714	Zhang HY,Chang H,Fan XN,et al. Expression of adhesion molecules and mucins in human and rhesus macaque gastrointestinal epithelial cells[J]. HISTOLOGY AND HISTOPATHOLOGY,2011,26(11):1405-1413.
APA	Zhang HY.,Chang H.,Fan XN.,Zhang KD.,Yu L.,...&caoy@mail.kiz.ac.cn.(2011).Expression of adhesion molecules and mucins in human and rhesus macaque gastrointestinal epithelial cells.HISTOLOGY AND HISTOPATHOLOGY,26(11),1405-1413.
MLA	Zhang HY,et al."Expression of adhesion molecules and mucins in human and rhesus macaque gastrointestinal epithelial cells".HISTOLOGY AND HISTOPATHOLOGY 26.11(2011):1405-1413.

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