Complement Inhibition Enables Renal Allograft Accommodation and Long-Term Engraftment in Presensitized Nonhuman Primates

KIZ OpenIR > 其他

	Complement Inhibition Enables Renal Allograft Accommodation and Long-Term Engraftment in Presensitized Nonhuman Primates
	Chen S 1; Zhong S 1; Xiang Y 1; Li JH 1; Guo H 1; Wang WY 2; Xiong YL 2; Li XC 3; Chen S 1,4,5; Chen XP 1,4,5; Chen G*1,4,5; gchen@tjh.tjmu.edu.cn
	2011
发表期刊	AMERICAN JOURNAL OF TRANSPLANTATION
卷号	11 期号:10 页码:2057-2066
合作性质	其它
摘要	Protection against humoral injury mediated by donor-specific antibodies (DSA), also known as accommodation, may allow for long-term allograft survival in presensitized recipients. In the present study, we determined the role of complement in renal allograft accommodation in donor skin-presensitized nonhuman primates under conventional immunosuppression. Donor skin allografts were transplanted to presensitized recipients 14 days prior to renal transplantation. Renal allografts not receiving any immunosuppressive treatment developed accelerated rejection with predominantly humoral injury, which was not prevented using conventional cyclosporine (CsA) triple therapy. Inhibition of complement activation with the Yunnan-cobra venom factor (Y-CVF) successfully prevented accelerated antibody-mediated rejection and resulted in successful accommodation and long-term renal allograft survival in most presensitized recipients. Accommodation in this model was associated with the prevention of the early antibody responses induced against donor antigens by complement inhibition. Some antiapoptotic proteins and complement regulatory proteins, including Bcl-2, CD59, CD46 and clusterin, were upregulated in the surviving renal allografts. These results suggest that the complement inhibition-based strategy may be valuable alternative in future clinical cross-match positive or ABO-incompatible transplantation.
关键词	Accommodation Acute Humoral Rejection Complement Inhibition Monkey Renal Allograft
资助者	The authors thank Hong Wang, Jianguo Zhu and Ying Wu for excellent postoperative studies and animal care. This work was supported by Na- tional Natural Science Foundation of China (30500470 and 30872384) to G. Chen. ; The authors thank Hong Wang, Jianguo Zhu and Ying Wu for excellent postoperative studies and animal care. This work was supported by Na- tional Natural Science Foundation of China (30500470 and 30872384) to G. Chen. ; The authors thank Hong Wang, Jianguo Zhu and Ying Wu for excellent postoperative studies and animal care. This work was supported by Na- tional Natural Science Foundation of China (30500470 and 30872384) to G. Chen. ; The authors thank Hong Wang, Jianguo Zhu and Ying Wu for excellent postoperative studies and animal care. This work was supported by Na- tional Natural Science Foundation of China (30500470 and 30872384) to G. Chen.
收录类别	SCI
语种	英语
资助者	The authors thank Hong Wang, Jianguo Zhu and Ying Wu for excellent postoperative studies and animal care. This work was supported by Na- tional Natural Science Foundation of China (30500470 and 30872384) to G. Chen. ; The authors thank Hong Wang, Jianguo Zhu and Ying Wu for excellent postoperative studies and animal care. This work was supported by Na- tional Natural Science Foundation of China (30500470 and 30872384) to G. Chen. ; The authors thank Hong Wang, Jianguo Zhu and Ying Wu for excellent postoperative studies and animal care. This work was supported by Na- tional Natural Science Foundation of China (30500470 and 30872384) to G. Chen. ; The authors thank Hong Wang, Jianguo Zhu and Ying Wu for excellent postoperative studies and animal care. This work was supported by Na- tional Natural Science Foundation of China (30500470 and 30872384) to G. Chen.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/353002/6820
专题	其他
通讯作者	gchen@tjh.tjmu.edu.cn
作者单位	1.Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 2.Animal Toxicological Laboratory, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, China 3.The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 4.Key Laboratory of Organ Transplantation, Ministry of Education, China 5.Key Laboratory of Organ Transplantation, Ministry of Public Health, China
推荐引用方式 GB/T 7714	Chen S,Zhong S,Xiang Y,et al. Complement Inhibition Enables Renal Allograft Accommodation and Long-Term Engraftment in Presensitized Nonhuman Primates[J]. AMERICAN JOURNAL OF TRANSPLANTATION,2011,11(10):2057-2066.
APA	Chen S.,Zhong S.,Xiang Y.,Li JH.,Guo H.,...&gchen@tjh.tjmu.edu.cn.(2011).Complement Inhibition Enables Renal Allograft Accommodation and Long-Term Engraftment in Presensitized Nonhuman Primates.AMERICAN JOURNAL OF TRANSPLANTATION,11(10),2057-2066.
MLA	Chen S,et al."Complement Inhibition Enables Renal Allograft Accommodation and Long-Term Engraftment in Presensitized Nonhuman Primates".AMERICAN JOURNAL OF TRANSPLANTATION 11.10(2011):2057-2066.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2011102101.pdf（857KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文