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Discovery of L15 as a novel Vif PROTAC degrader with antiviral activity against HIV-1 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 111
作者:  Luo, D;  Luo, RH;  Wang, WL;  Deng, R;  Wang, SR;  Ma, XY;  Pu, CL;  Liu, YY;  Zhang, HJ;  Yu, S;  Huang, Q;  Yang, LM;  Tong, Y;  Zheng, YT;  Li, R
Adobe PDF(5020Kb)  |  收藏  |  浏览/下载：153/0  |  提交时间：2025/04/09
Design, synthesis, and biological evaluation of 2-amino-N-(2methoxyphenyl)-6-((4-nitrophenyl)sulfonyl)benzamide derivatives as potent HIV-1 Vif inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 24
作者:  Zhang, RH;  Wang, S;  Luo, RH;  Zhou, M;  Zhang, H;  Xu, GB;  Zhao, YL;  Li, YJ;  Wang, YL;  Yan, GY;  Liao, SG;  Zheng, YT;  Li, R
Adobe PDF(1215Kb)  |  收藏  |  浏览/下载：39/0  |  提交时间：2023/04/18
Design, synthesis and biological evaluation of indole derivatives as Vif inhibitors 期刊论文
Bioorganic & Medicinal Chemistry Letters, 2017, 卷号: **, 期号: **, 页码: Epub ahead of print
作者:  Pu CL;  Luo RH;  Luo J;  Zheng YT*;  Li R*;  Zhang MQ;  Hou XY;  Yan GY
Adobe PDF(1678Kb)  |  收藏  |  浏览/下载：103/1  |  提交时间：2017/07/31
Apobec3g Degradation  Fbvs  Indole Derivatives  Vif Inhibitor  
Isocostunolide inhibited glioma stem cell by suppression proliferation and inducing caspase dependent apoptosis 期刊论文
Bioorganic & Medicinal Chemistry Letters, 2017, 卷号: **, 期号: **, 页码: In press
作者:  Dai Z;  Li SR;  Liu YP;  Luo XD*;  Zhao XD*;  Zhu PF;  Liu L;  Wang B;  xdluo@mail.kib.ac.cn;  zhaoxudong@mail.kiz.ac.cn
Adobe PDF(2245Kb)  |  收藏  |  浏览/下载：83/2  |  提交时间：2017/05/15
Isocostunolide  Glioma Stem Cells  Cell Proliferation  Apoptosis  Colony Formation  
Design, synthesis and anti-HIV-1 RT evaluation of 2-(benzyl(4-chlorophenyl)amino)-1-(piperazin-1-yl)ethanone derivatives 期刊论文
Bioorganic & Medicinal Chemistry Letters, 2017, 卷号: 27, 期号: 1, 页码: 61-65
作者:  Chander S;  Pang W;  Sankaranarayanan M*;  Ashok P;  Yang LM;  Zheng YT*;  zhengyt@mail.kiz.ac.cn
Adobe PDF(907Kb)  |  收藏  |  浏览/下载：104/2  |  提交时间：2016/12/01
Enzymatic Assay  Wild Strain  Reverse Transcriptase  Docking  Cytotoxicity  
Structural modifications of 5,6-dihydroxypyrimidines with anti-HIV activity 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 卷号: 22, 期号: 23, 页码: 7114-7118
作者:  Guo DL;  Zhang XJ;  Wang RR;  Zhou Y;  Li Z;  Xu JY;  Chen KX;  Zheng YT*;  Liu H*;  zhengyt@mail.kiz.ac.cn;  hliu@mail.shcnc.ac.cn
Adobe PDF(766Kb)  |  收藏  |  浏览/下载：119/2  |  提交时间：2013/04/09
Dihydroxypyrimidine  Synthesis  Hiv  Integrase Inhibitor  Docking Study  
Synthesis and biological evaluation of novel amprenavir-based P1-substituted bi-aryl derivatives as ultra-potent HIV-1 protease inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 卷号: 22, 期号: 5, 页码: 1976-1979
作者:  Yan JW;  Huang N;  Li SK;  Yang LM;  Xing WQ;  Zheng YT*;  Hu YH*;  zhengyt@mail.kiz.ac.cn;  yhhu@mail.shcnc.ac.cn
Adobe PDF(409Kb)  |  收藏  |  浏览/下载：162/5  |  提交时间：2012/03/19
Hiv-1 Protease Inhibitors  Amprenavir  Darunavir Biaryl Compounds  Docking Study  
Synthesis and biological evaluation of novel dihydro-aryl/alkylsulfanyl-cyclohexylmethyl-oxopyrimidines (S-DACOs) as high active anti-HIV agents 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 卷号: 21, 期号: 2, 页码: 694-697
作者:  He YP*;  Long J;  Zhang SS;  Li C;  Lai CC;  Zhang CS;  Li DX;  Zhang DH;  Wang H;  Cai QQ;  Zheng YT*;  yphe@ynu.edu.cn;  zhengyt@mail.kiz.ac.cn
Adobe PDF(395Kb)  |  收藏  |  浏览/下载：1658/7  |  提交时间：2011/03/15
Nnrtis  S-dabos  S-dacos  Anti Hiv-1 Activity  
Synthesis and biological evaluation of naphthyl phenyl ethers (NPEs) as novel nonnucleoside HIV-1 reverse transcriptase inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 卷号: 19, 期号: 14, 页码: 4220-4226
作者:  Gu SX;  Zhang X;  Zheng YT;  Yang SQ;  Chen FE*;  He QQ;  Yang LM;  Ma XD;  rfchen@fudan.edu.cn
Adobe PDF(416Kb)  |  收藏  |  浏览/下载：55/1  |  提交时间：2016/08/30
Hiv-1 Reverse Transcriptase  Nnrtis  Npes  Sar  Anti-hiv Activity  
Anti HIV-1 agents 5: Synthesis and anti-HIV-1 activity of some N-arylsulfonyl-3-acetylindoles in vitro 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 卷号: 20, 期号: 12, 页码: 3534-3536
作者:  Ran JQ;  Huang N;  Xu H[*];  Yang LM;  Lv M[*];  Zheng YT[*];  orgxuhui@nwsuaf.edu.cn;  lvmin@nwsuaf.edu.cn;  zhengyt@mail.kiz.ac.cn
Adobe PDF(238Kb)  |  收藏  |  浏览/下载：121/3  |  提交时间：2010/08/24
N-arylsulfonyl-3-acetylindole  Acquired Immune-deficiency Syndrome  Human Immunodeficiency Virus-1  Inhibitor