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Discovery and structure-activity relationship studies of novel a-ketoamide derivatives targeting the SARS-CoV-2 main protease 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 259
作者:  Huang, C;  Zeng, R;  Qiao, JX;  Quan, BX;  Luo, RH;  Huang, Q;  Guo, NH;  Li, YY;  Long, XY;  Ma, RG;  Xia, AJ;  Fang, Z;  Wang, YF;  Li, YS;  Zheng, YT;  Li, LL;  Lei, J;  Yang, SY
Adobe PDF(4197Kb)  |  收藏  |  浏览/下载：146/0  |  提交时间：2024/06/21
Discovery of dehydroandrographolide derivatives with C19 hindered ether as potent anti-ZIKV agents with inhibitory activities to MTase of ZIKV NS5 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 243
作者:  Qian, WY;  Zhou, GF;  Ge, XT;  Xue, JX;  Zheng, CB;  Yang, LM;  Gu, XR;  Li, CY;  Xiong, SD;  Zheng, YT;  Zhou, GC
Adobe PDF(4648Kb)  |  收藏  |  浏览/下载：41/0  |  提交时间：2023/04/18
Novel nucleocapsid protein-targeting phenanthridine inhibitors of SARS-CoV-2 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 227
作者:  Wang, YT;  Long, XY;  Ding, X;  Fan, SR;  Cai, JY;  Yang, BJ;  Zhang, XF;  Luo, RH;  Yang, L;  Ruan, T;  Ren, J;  Jing, CX;  Zheng, YT;  Hao, XJ;  Chen, DZ
Adobe PDF(2966Kb)  |  收藏  |  浏览/下载：179/0  |  提交时间：2023/04/18
Lead optimization to improve the antiviral potency of 2-aminobenzamide derivatives targeting HIV-1 Vif-A3G axis 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 224
作者:  Zhong, XX;  Luo, RH;  Yan, GY;  Ran, K;  Shan, HF;  Yang, J;  Liu, YY;  Yu, S;  Pu, CL;  Zheng, YT;  Li, R
Adobe PDF(1183Kb)  |  收藏  |  浏览/下载：164/0  |  提交时间：2023/04/18
Discovery of novel mifepristone derivatives via suppressing KLF5 expression for the treatment of triple-negative breast cancer 期刊论文
European Journal of Medicinal Chemistry, 2018, 期号: 146, 页码: 354-367
作者:  Yuqi Lin;  Ping Zhao;  Jinxiang Ye;  Zheng Zheng;  Jingan Huang;  Yingying Zhang;  Yu Gao;  Haiying Chen;  Suling Liu;  Jia Zhou;  Ceshi Chen;  Haijun Chen
Adobe PDF(1560Kb)  |  收藏  |  浏览/下载：56/0  |  提交时间：2018/09/25
Triple-negative Breast Cancer  Mifepristone Derivatives  Sensitive Metabolic Region  Klf5 Expression  
Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction 期刊论文
European Journal of Medicinal Chemistry, 2017, 卷号: 125, 期号: X, 页码: 1051-1063
作者:  Zhang FH;  Debnath B;  Zheng YT;  Neamati N*;  Long YQ*;  Xu ZL;  Yang LM;  Song LR;  neamati@umich.edu
Adobe PDF(2261Kb)  |  收藏  |  浏览/下载：124/2  |  提交时间：2016/11/07
3-hydroxypicolinamide  Allosteric Inhibitor  Dimerization  Hiv-1 Integrase  Ledgf/p75  
Synthesis, biological evaluation and molecular docking study of N-(2-methoxyphenyl)-6-((4-nitrophenyl)sulfonyl)benzamide derivatives as potent HIV-1 Vif antagonists 期刊论文
European Journal of Medicinal Chemistry, 2017, 卷号: 129, 期号: X, 页码: 310-324
作者:  Zhou M;  Luo RH;  Chen H;  Zhang RH;  Shi JY;  Zheng YT*;  Li R*;  Wei YQ;  Hou XY;  Wang RR;  Yan GY;  zhengyt@mail.kiz.ac.cn;  lirui@scu.edu.cn
Adobe PDF(1467Kb)  |  收藏  |  浏览/下载：138/2  |  提交时间：2017/02/28
Antiviral Activity  Nonpermissive  Vif Antagonists  Vif Mediated A3g Degradation  
Synthesis, structure-activity relationships, and docking studies of N-phenylarylformamide derivatives (PAFAs) as non-nucleoside HIV reverse transcriptase inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 卷号: 58, 期号: X, 页码: 504-512
作者:  Ma XD;  He QQ;  Zhang X;  Yang SQ;  Yang LM;  Gu SX;  Zheng YT;  Chen FE*;  Dai HF*;  rfchen@fudan.edu.cn
Adobe PDF(825Kb)  |  收藏  |  浏览/下载：136/3  |  提交时间：2013/03/08
Anti-hiv Activity  Nnrtis  Benzophenone Derivatives  N-phenylarylformamide  Structure-activity Relationship