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Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction 期刊论文
European Journal of Medicinal Chemistry, 2017, 卷号: 125, 期号: X, 页码: 1051-1063
作者:  Zhang FH;  Debnath B;  Zheng YT;  Neamati N*;  Long YQ*;  Xu ZL;  Yang LM;  Song LR;  neamati@umich.edu
Adobe PDF(2261Kb)  |  收藏  |  浏览/下载：124/2  |  提交时间：2016/11/07
3-hydroxypicolinamide  Allosteric Inhibitor  Dimerization  Hiv-1 Integrase  Ledgf/p75  
Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 12, 页码: 3146-3158
作者:  Li BW;  Zhang FH;  Serrao E;  Chen H;  Sanchez TW;  Yang LM;  Neamati N;  Zheng YT;  Wang H*;  Long YQ*;  huiwang@scnu.edu.cn;  yqlong@mail.shcnc.ac.cn
Adobe PDF(1380Kb)  |  收藏  |  浏览/下载：322/2  |  提交时间：2014/10/15
Chelation  Strand Transfer  Ledgf/p75  Hiv-1 Integrase Inhibitors  Flavonoid  
Discovery of a novel HIV-1 integrase inhibitor from natural compounds through structure based virtual screening and cell imaging 期刊论文
FEBS LETTERS, 2014, 卷号: 588, 期号: 18, 页码: 3461-3468
作者:  Gu WG;  Zhang X;  Ip DTM;  Yang LM;  Zheng YT;  Wan DCC*;  chicheongwan@cuhk.edu.hk
Adobe PDF(2283Kb)  |  收藏  |  浏览/下载：134/3  |  提交时间：2014/10/10
Hiv-1 Integrase  Lens Epithelium-derived Growth Factor (Ledgf/p75)  Virtual Screening  
1,4-Bis(5-(naphthalen-1-yl)thiophen-2-yl)naphthalene, a small molecule, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular Lens epithelium-derived growth factor 期刊论文
CHEMICO-BIOLOGICAL INTERACTIONS, 2014, 卷号: 213, 期号: X, 页码: 21-27
作者:  Gu WG;  Ip DTM;  Liu SJ;  Chan JH;  Wang Y;  Zhang X;  Zheng YT;  Wan DCC*;  chicheongwan@cuhk.edu.hk
Adobe PDF(1448Kb)  |  收藏  |  浏览/下载：102/2  |  提交时间：2014/10/15
Hiv-1 Integrase  Lens Epithelium-derived Growth Factor (Ledgf/p75  Molecular Docking  
Wikstroelide M potently inhibits HIV replication by targeting reverse transcriptase and integrase nuclear translocation 期刊论文
Chinese Journal of Natural Medicines, 2014, 卷号: 12, 期号: 3, 页码: 186-193
作者:  Zhang X;  Huang SZ;  Gu WG;  Yang LM;  Chen H;  Zheng CB;  Zhao YX;  Wan David DC;  Zheng YT*;  zhengyt@mail.kiz.ac.cn
Adobe PDF(1209Kb)  |  收藏  |  浏览/下载：5640/3  |  提交时间：2014/06/03
Wikstroelide m  Daphnane Diterpene  Daphne Acutiloba Rehder  Hiv  Reverse Trascriptase  Integrase  Nuclear Translocation  Lens Epithelium-derived Growth Factor (Ledgf/p75)  Molecular Docking  
D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75 期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 卷号: 375, 期号: 1, 页码: 139-144
作者:  Du L;  Chen JX;  Chen J;  Yang LM;  Zheng YT;  Tang Y*;  Shen X*;  Jiang HL;  ytang234@ecust.edu.cn;  xshen@mail.shcnc.ac.cn
Adobe PDF(720Kb)  |  收藏  |  浏览/下载：120/3  |  提交时间：2010/08/24
Hiv-1 Integrase  Lens Epithelium-derived Growth Factor (Ledgf/p75)  Yeast Two-hybrid Assay  Surface Plasmon Resonance (Spr)  Molecular Docking  Site-directed Mutagenesis