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利用转录组数据探究人类复杂疾病 学位论文
理学博士, 北京: 中国科学院大学, 2018
作者:  王倩
Adobe PDF(2732Kb)  |  收藏  |  浏览/下载：3395/0  |  提交时间：2020/12/15
转录组整合分析,帕金森病,阿茨海默症,癌症总生存期,T细胞受体信号通路  transcriptome Integrative Analysis, Parkinson's Disease, Alzheimer's Disease, Cancer Overall Survival, t Cell Receptor Signaling Pathway  
Vesicular glutamate transporter 1 (VGLUT1)-mediated glutamate release and membrane GluA1 activation is involved in the rapid antidepressant-like effects of scopolamine in mice 期刊论文
Neuropharmacology, 2018, 期号: 131, 页码: 209-222
作者:  Hanjie Yu;  Mengmeng Li;  Dongsheng Zhou;  Dan Lv;  Qi Liao;  Zhongze Lou;  Mengxin Shen;  Zhen Wang;  Ming Li;  Xiao Xiao;  Yanhua Zhang;  Chuang Wang
Adobe PDF(4743Kb)  |  收藏  |  浏览/下载：71/0  |  提交时间：2018/09/28
Scopolamine  a -amino-3-hydroxy-5-methyl-4-  Isoxazolepropionic Acid Receptor (Ampar)  Vesicular Glutamate Transporter 1 (Vglut1)  Brain-derived Neurotrophic Factor (Bdnf)  Vgf (Non-acronymic)  Bicaudal c Homolog 1 Gene (Bicc1)  
LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes 期刊论文
PNAS, 2018, 卷号: 115, 期号: 15, 页码: 3948–3953
作者:  Nengyin Sheng;  Michael A. Bemben;  Javier Díaz-Alonso;  Wucheng Tao;  Yun Stone Shi;  Roger A. Nicoll
Adobe PDF(1037Kb)  |  收藏  |  浏览/下载：2841/0  |  提交时间：2018/09/26
Long-term Potentiation  Glutamate Receptor  Auxiliary Protein  Pdz-binding Domain  
a functional snP upstream of the ADRB2 gene is associated with COPD 期刊论文
International Journal of COPD, 2018, 期号: 13, 页码: 917–925
作者:  Jin-Xiu li;  li Yu;  Ya-Ping Zhang;  Xiao- hua Zhang;  Chang sun;  lu-Ming Dai;  li Zhong
Adobe PDF(812Kb)  |  收藏  |  浏览/下载：49/0  |  提交时间：2018/09/25
β 2 -adrenergic Receptor  Adrb2  Fev 1  Lung  Polymorphism  
An inhibitor peptide of toll-like receptor 2 shows therapeutic potential for allergic conjunctivitis 期刊论文
International Immunopharmacology, 2017, 卷号: 46, 期号: X, 页码: 9-15
作者:  Xu C;  He XQ;  Duan ZL;  Lu QM;  Yan XW*;  Zhang ZY*;  Zheng RQ*;  Liu WH;  Chen Y;  Zhou CL;  yanxw@njau.edu.cn;  zhangzhiye5225@163.com;  13952721411@163.com
Adobe PDF(2307Kb)  |  收藏  |  浏览/下载：151/1  |  提交时间：2017/03/03
Allergy Conjunctivitis  Immunoregulatory Peptide  Toll Like Receptor 2  Staphylococcal Enterotoxin b  
冬凌草甲素衍生物CYD-6-28抗三阴性乳腺癌的作用和机制研究 学位论文
, 北京: 中国科学院大学, 2017
作者:  吴静
Adobe PDF(5766Kb)  |  收藏  |  浏览/下载：100/0  |  提交时间：2019/12/18
冬凌草甲素衍生物  凋亡  亡受体5  三阴性乳腺癌  Oridonin Analog  Apoptosis  Death Receptor 5 (Dr5)  Triple-negative Breast Cancer (Tnbc)  
DAT1 methylation is associated with methylphenidate response on oppositional and hyperactive-impulsive symptoms in children and adolescents with ADHD 期刊论文
THE WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 2017, 卷号: 18, 期号: 4, 页码: 291–299
作者:  Ding KJ;  Yang JZ;  Liu RX;  Qian QJ;  Liu H;  Yang RX;  Wen JF*;  Kang CY*;  Reynolds GP;  Chen B;  Shao JR;  kangbao98@163.com
Adobe PDF(1105Kb)  |  收藏  |  浏览/下载：85/1  |  提交时间：2017/10/17
Attention Deficit  Hyperactivity Disorder  Dna Methylation  Dopamine Transporter Gene (Dat1/ Slc6a3)  Dopamine Receptor D4 Gene (drD4)  Methylphenidate Efficacy  
A new oridonin analog suppresses triple-negative breast cancer cells and tumor growth via the induction of death receptor 5 期刊论文
CANCER LETTERS, 2016, 卷号: 380, 期号: 2, 页码: 393-402
作者:  Wu J;  Ding Y;  Chen HY;  Zhou J*;  Chen CS*;  Chen CH;  Zhou ZM;  Ding CY;  jizhou@utmb.edu;  chenc@mail.kiz.ac.cn
Adobe PDF(4104Kb)  |  收藏  |  浏览/下载：80/3  |  提交时间：2016/10/24
Oridonin Analog  Apoptosis  Death Receptor 5 (Dr5)  Triple-negative Breast Cancer  Therapy  
Selective Activation of Nociceptor TRPV1 Channel and Reversal of Inflammatory Pain in Mice by a Novel Coumarin Derivative Muralatin L from Murraya alata 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 卷号: 192, 期号: 2, 页码: 640-651
作者:  Wei NN;  Lv HN;  Wu Y;  Yang SL;  Sun XY;  Lai R;  Jiang Y*;  Wang KW*;  yongjiang@bjmu.edu.cn;  wangkw@bjmu.edu.cn
Adobe PDF(3131Kb)  |  收藏  |  浏览/下载：123/3  |  提交时间：2016/03/04
Calcium  Calcium Imaging  Drug Discovery  Drug Screening  Ion Channel  Neuron  Transient Receptor Potential Channels (Trp Channels)  
Escitalopram attenuates beta-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT1A receptor mediated Akt/GSK-3 beta pathway 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 12, 页码: 13328-13339
作者:  Wang YJ;  Ren QG*;  Li XL;  Wu FF;  Bai F;  Xu L;  Zhang ZJ*;  Gong WG;  Wu D;  Tang X;  renqingguo1976@163.com;  janemengzhang@vip.163.com
Adobe PDF(9931Kb)  |  收藏  |  浏览/下载：117/2  |  提交时间：2016/07/20
Alzheimer's Disease  Tau Protein  Escitalopram  Akt/gsk-3 Beta Pathway  5-ht1a Receptor  Gerotarget