Ancient Hybridization with an Unknown Population Facilitated High-Altitude Adaptation of Canids

	Ancient Hybridization with an Unknown Population Facilitated High-Altitude Adaptation of Canids
	Wang, Ming-Shan; Wang, Sheng; Li, Yan; Jhala, Yadvendradev; Thakur, Mukesh; Otecko, Newton O.; Si, Jing-Fang; Chen, Hong-Man; Shapiro, Beth; Nielsen, Rasmus; Zhang, Ya-Ping; Wu, Dong-Dong
	2020
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
卷号	37 期号:9 页码:2616-2629
摘要	Genetic introgression not only provides material for adaptive evolution but also confounds our understanding of evolutionary history. This is particularly true for canids, a species complex in which genome sequencing and analysis has revealed a complex history of admixture and introgression. Here, we sequence 19 new whole genomes from high-altitude Tibetan and Himalayan wolves and dogs and combine these into a larger data set of 166 whole canid genomes. Using these data, we explore the evolutionary history and adaptation of these and other canid lineages. We find that Tibetan and Himalayan wolves are closely related to each other, and that similar to 39% of their nuclear genome is derived from an asyet-unrecognized wolf-like lineage that is deeply diverged from living Holarctic wolves and dogs. The EPAS1 haplotype, which is present at high frequencies in Tibetan dog breeds and wolves and confers an adaptive advantage to animals living at high altitudes, was probably derived from this ancient lineage. Our study underscores the complexity of canid evolution and demonstrates how admixture and introgression can shape the evolutionary trajectories of species.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12794
专题	科研部门_进化与发育转录组学（吴东东）
推荐引用方式 GB/T 7714	Wang, Ming-Shan,Wang, Sheng,Li, Yan,et al. Ancient Hybridization with an Unknown Population Facilitated High-Altitude Adaptation of Canids[J]. MOLECULAR BIOLOGY AND EVOLUTION,2020,37(9):2616-2629.
APA	Wang, Ming-Shan.,Wang, Sheng.,Li, Yan.,Jhala, Yadvendradev.,Thakur, Mukesh.,...&Wu, Dong-Dong.(2020).Ancient Hybridization with an Unknown Population Facilitated High-Altitude Adaptation of Canids.MOLECULAR BIOLOGY AND EVOLUTION,37(9),2616-2629.
MLA	Wang, Ming-Shan,et al."Ancient Hybridization with an Unknown Population Facilitated High-Altitude Adaptation of Canids".MOLECULAR BIOLOGY AND EVOLUTION 37.9(2020):2616-2629.

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