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Discovery of L15 as a novel Vif PROTAC degrader with antiviral activity against HIV-1 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 111
作者:  Luo, D;  Luo, RH;  Wang, WL;  Deng, R;  Wang, SR;  Ma, XY;  Pu, CL;  Liu, YY;  Zhang, HJ;  Yu, S;  Huang, Q;  Yang, LM;  Tong, Y;  Zheng, YT;  Li, R
Adobe PDF(5020Kb)  |  收藏  |  浏览/下载:153/0  |  提交时间:2025/04/09
Design, synthesis, and biological evaluation of 2-amino-N-(2methoxyphenyl)-6-((4-nitrophenyl)sulfonyl)benzamide derivatives as potent HIV-1 Vif inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 24
作者:  Zhang, RH;  Wang, S;  Luo, RH;  Zhou, M;  Zhang, H;  Xu, GB;  Zhao, YL;  Li, YJ;  Wang, YL;  Yan, GY;  Liao, SG;  Zheng, YT;  Li, R
Adobe PDF(1215Kb)  |  收藏  |  浏览/下载:39/0  |  提交时间:2023/04/18
Synthesis and structure–activity relationship studies of MI-2 analogues as MALT1 inhibitors 期刊论文
Bioorganic & Medicinal Chemistry, 2018, 期号: 26, 页码: 3321–3344
作者:  Guolin Wu;  Haijun Chen;  Wenhui Zhou;  Bihua Zeng;  Wenhui Mo;  Kejie Zhu;  Rong Liu;  Jia Zhou;  Ceshi Chen
Adobe PDF(2528Kb)  |  收藏  |  浏览/下载:52/1  |  提交时间:2018/09/28
Malt1  Mi-2 Analogues  Structure–activity Relationships  Cancer Therapeutics  
Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells 期刊论文
Bioorganic & Medicinal Chemistry, 2018, 期号: 26, 页码: 1776–1783
作者:  Xin Wei;  Xu-Dong Zhao;  Jing Yang;  Xiao-Dong Luo;  Afsar Khan;  Hao-Fei Yu;  Yun-Li Zhao;  Yi-Fen Wang;  Ya-Ping Liu;  Zi-Feng Yang;  Wan-Yi Huang;  Xin-Hua Wang
Adobe PDF(2099Kb)  |  收藏  |  浏览/下载:66/0  |  提交时间:2018/09/27
Alstoniasidines a And b  Sugar Bridged Bisindole  Glioma Stem Cells  Alstonia Scholaris  
Design, synthesis and biological evaluation of indole derivatives as Vif inhibitors 期刊论文
Bioorganic & Medicinal Chemistry Letters, 2017, 卷号: **, 期号: **, 页码: Epub ahead of print
作者:  Pu CL;  Luo RH;  Luo J;  Zheng YT*;  Li R*;  Zhang MQ;  Hou XY;  Yan GY
Adobe PDF(1678Kb)  |  收藏  |  浏览/下载:104/1  |  提交时间:2017/07/31
Apobec3g Degradation  Fbvs  Indole Derivatives  Vif Inhibitor  
Isocostunolide inhibited glioma stem cell by suppression proliferation and inducing caspase dependent apoptosis 期刊论文
Bioorganic & Medicinal Chemistry Letters, 2017, 卷号: **, 期号: **, 页码: In press
作者:  Dai Z;  Li SR;  Liu YP;  Luo XD*;  Zhao XD*;  Zhu PF;  Liu L;  Wang B;  xdluo@mail.kib.ac.cn;  zhaoxudong@mail.kiz.ac.cn
Adobe PDF(2245Kb)  |  收藏  |  浏览/下载:84/2  |  提交时间:2017/05/15
Isocostunolide  Glioma Stem Cells  Cell Proliferation  Apoptosis  Colony Formation  
Design, synthesis and anti-HIV-1 RT evaluation of 2-(benzyl(4-chlorophenyl)amino)-1-(piperazin-1-yl)ethanone derivatives 期刊论文
Bioorganic & Medicinal Chemistry Letters, 2017, 卷号: 27, 期号: 1, 页码: 61-65
作者:  Chander S;  Pang W;  Sankaranarayanan M*;  Ashok P;  Yang LM;  Zheng YT*;  zhengyt@mail.kiz.ac.cn
Adobe PDF(907Kb)  |  收藏  |  浏览/下载:105/2  |  提交时间:2016/12/01
Enzymatic Assay  Wild Strain  Reverse Transcriptase  Docking  Cytotoxicity  
Design, synthesis and anti-HIV-1 evaluation of hydrazide-based peptidomimetics as selective gelatinase inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 卷号: 24, 期号: 9, 页码: 2125-2136
作者:  Yang L;  Wang P;  Pang W;  Li YG;  Shen YM;  Zheng YT*;  Li X*;  Wu JF;  Yang LM;  Wang RR;  zhengyt@mail.kiz.ac.cn;  tjulx2004@sdu.edu.cn
Adobe PDF(3521Kb)  |  收藏  |  浏览/下载:121/4  |  提交时间:2016/04/05
Hydrazide Derivatives  Quinoxalinone  Selective Gelatinase Inhibitors  Peptidomimetics  Anti-hiv Activity  
Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 12, 页码: 3146-3158
作者:  Li BW;  Zhang FH;  Serrao E;  Chen H;  Sanchez TW;  Yang LM;  Neamati N;  Zheng YT;  Wang H*;  Long YQ*;  huiwang@scnu.edu.cn;  yqlong@mail.shcnc.ac.cn
Adobe PDF(1380Kb)  |  收藏  |  浏览/下载:322/2  |  提交时间:2014/10/15
Chelation  Strand Transfer  Ledgf/p75  Hiv-1 Integrase Inhibitors  Flavonoid  
Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 14, 页码: 4218-4224
作者:  Zhu JM;  Wu CF;  Li XB;  Wu GS;  Xie S;  Hu QN;  Deng ZX;  Zhu MX*;  Luo HR*;  Hong XC*;  Michael.X.Zhu@uth.tmc.edu;  luohuairong@mail.kib.ac.cn;  xhy78@whu.edu.cn
Adobe PDF(1174Kb)  |  收藏  |  浏览/下载:161/2  |  提交时间:2014/10/17
Butyrylcholinesterase  Acetylcholinesterase  Molecular Modeling  2-aminobenzimidazole  Alzheimer's Disease