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Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction 期刊论文
European Journal of Medicinal Chemistry, 2017, 卷号: 125, 期号: X, 页码: 1051-1063
作者:  Zhang FH;  Debnath B;  Zheng YT;  Neamati N*;  Long YQ*;  Xu ZL;  Yang LM;  Song LR;  neamati@umich.edu
Adobe PDF(2261Kb)  |  收藏  |  浏览/下载：124/2  |  提交时间：2016/11/07
3-hydroxypicolinamide  Allosteric Inhibitor  Dimerization  Hiv-1 Integrase  Ledgf/p75  
Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 12, 页码: 3146-3158
作者:  Li BW;  Zhang FH;  Serrao E;  Chen H;  Sanchez TW;  Yang LM;  Neamati N;  Zheng YT;  Wang H*;  Long YQ*;  huiwang@scnu.edu.cn;  yqlong@mail.shcnc.ac.cn
Adobe PDF(1380Kb)  |  收藏  |  浏览/下载：322/2  |  提交时间：2014/10/15
Chelation  Strand Transfer  Ledgf/p75  Hiv-1 Integrase Inhibitors  Flavonoid  
Repositioning HIV‑1 Integrase Inhibitors for Cancer Therapeutics: 1,6-Naphthyridine-7-carboxamide as a Promising Scaffold with Drug-like Properties 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2012, 卷号: 55, 期号: 22, 页码: 9492-9509
作者:  Zeng LF;  Wang Y;  Kazemi R;  Xu SL;  Xu ZL;  Sanchez TW;  Yang LM;  Debnath B;  Odde S;  Xie H;  Zheng YT;  Ding J;  Neamati N*;  Long YQ*;  neamati@usc.edu;  yqlong@mail.shcnc.ac.cn
Adobe PDF(4995Kb)  |  收藏  |  浏览/下载：145/4  |  提交时间：2013/04/09
Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 卷号: 18, 期号: 16, 页码: 4521-4524
作者:  Zeng LF;  Zhang HS;  Wang YH;  Sanchez T;  Zheng YT;  Neamati N;  Long YQ*;  yqlong@mail.shcnc.ac.cn
Adobe PDF(267Kb)  |  收藏  |  浏览/下载：115/3  |  提交时间：2010/08/24
Hiv-1 Integrase Inhibitor  Bioisostere  Heteroaromatic Carboxylic Acid  Isoxazole  Isothiazole  1h-pyrazole  Bioavailability  Antiviral Effect