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Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction 期刊论文
European Journal of Medicinal Chemistry, 2017, 卷号: 125, 期号: X, 页码: 1051-1063
作者:  Zhang FH;  Debnath B;  Zheng YT;  Neamati N*;  Long YQ*;  Xu ZL;  Yang LM;  Song LR;  neamati@umich.edu
Adobe PDF(2261Kb)  |  收藏  |  浏览/下载：124/2  |  提交时间：2016/11/07
3-hydroxypicolinamide  Allosteric Inhibitor  Dimerization  Hiv-1 Integrase  Ledgf/p75  
Synthesis and Anti-HIV-1 Activity Evaluation for Novel 3a,6a-Dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-dione Derivatives 期刊论文
Molecules, 2016, 卷号: 21, 期号: 9, 页码: e1198
作者:  Liu GN;  Luo RH;  Yang LM;  Zheng YT*;  Liu H*;  Zhou Y;  Zhang XJ;  Li J;  zhengyt@mail.kiz.ac.cn;  hliu@mail.shcnc.ac.cn
Adobe PDF(848Kb)  |  收藏  |  浏览/下载：120/4  |  提交时间：2016/09/18
Aids  Sar  Anti-hiv-1  Integrase  Synthesis  
Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 12, 页码: 3146-3158
作者:  Li BW;  Zhang FH;  Serrao E;  Chen H;  Sanchez TW;  Yang LM;  Neamati N;  Zheng YT;  Wang H*;  Long YQ*;  huiwang@scnu.edu.cn;  yqlong@mail.shcnc.ac.cn
Adobe PDF(1380Kb)  |  收藏  |  浏览/下载：322/2  |  提交时间：2014/10/15
Chelation  Strand Transfer  Ledgf/p75  Hiv-1 Integrase Inhibitors  Flavonoid  
Discovery of a novel HIV-1 integrase inhibitor from natural compounds through structure based virtual screening and cell imaging 期刊论文
FEBS LETTERS, 2014, 卷号: 588, 期号: 18, 页码: 3461-3468
作者:  Gu WG;  Zhang X;  Ip DTM;  Yang LM;  Zheng YT;  Wan DCC*;  chicheongwan@cuhk.edu.hk
Adobe PDF(2283Kb)  |  收藏  |  浏览/下载：134/3  |  提交时间：2014/10/10
Hiv-1 Integrase  Lens Epithelium-derived Growth Factor (Ledgf/p75)  Virtual Screening  
1,4-Bis(5-(naphthalen-1-yl)thiophen-2-yl)naphthalene, a small molecule, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular Lens epithelium-derived growth factor 期刊论文
CHEMICO-BIOLOGICAL INTERACTIONS, 2014, 卷号: 213, 期号: X, 页码: 21-27
作者:  Gu WG;  Ip DTM;  Liu SJ;  Chan JH;  Wang Y;  Zhang X;  Zheng YT;  Wan DCC*;  chicheongwan@cuhk.edu.hk
Adobe PDF(1448Kb)  |  收藏  |  浏览/下载：102/2  |  提交时间：2014/10/15
Hiv-1 Integrase  Lens Epithelium-derived Growth Factor (Ledgf/p75  Molecular Docking  
Synthesis and biological evaluation of 5-fluoroquinolone-3-carboxylic acids as potential HIV-1 integrase inhibitors 期刊论文
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2013, 卷号: 28, 期号: 4, 页码: 671-676
作者:  He QQ;  Zhang X;  Yang LM;  Zheng YT;  Chen F*;  rfchen@fudan.edu.cn
Adobe PDF(782Kb)  |  收藏  |  浏览/下载：100/3  |  提交时间：2013/08/27
Hiv-1 Integrase Inhibitor  5-fluoroquinolone-3-carboxylic Acids  Anti-hiv Activity  Metal Chelating  Structure-activity Relationship  
Symmetrical 1-pyrrolidineacetamide showing anti-HIV activity through a new binding site on HIV-1 integrase 期刊论文
ACTA PHARMACOLOGICA SINICA, 2008, 卷号: 29, 期号: 10, 页码: 1261-1267
作者:  Du L;  Zhao YX;  Yang LM;  Zheng YT;  Tang Y[*];  Shen X[*];  Jiang HL;  ytang234@ecust.edu.cn;  xshen@mail.shcnc.ac.cn
Adobe PDF(1145Kb)  |  收藏  |  浏览/下载：149/6  |  提交时间：2010/08/24
Hiv-1 Integrase Inhibitor  Surface Plasma Resonance  Molecular Docking  Site-directed Mutagenesis  
D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75 期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 卷号: 375, 期号: 1, 页码: 139-144
作者:  Du L;  Chen JX;  Chen J;  Yang LM;  Zheng YT;  Tang Y*;  Shen X*;  Jiang HL;  ytang234@ecust.edu.cn;  xshen@mail.shcnc.ac.cn
Adobe PDF(720Kb)  |  收藏  |  浏览/下载：120/3  |  提交时间：2010/08/24
Hiv-1 Integrase  Lens Epithelium-derived Growth Factor (Ledgf/p75)  Yeast Two-hybrid Assay  Surface Plasmon Resonance (Spr)  Molecular Docking  Site-directed Mutagenesis  
Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 卷号: 18, 期号: 16, 页码: 4521-4524
作者:  Zeng LF;  Zhang HS;  Wang YH;  Sanchez T;  Zheng YT;  Neamati N;  Long YQ*;  yqlong@mail.shcnc.ac.cn
Adobe PDF(267Kb)  |  收藏  |  浏览/下载：116/3  |  提交时间：2010/08/24
Hiv-1 Integrase Inhibitor  Bioisostere  Heteroaromatic Carboxylic Acid  Isoxazole  Isothiazole  1h-pyrazole  Bioavailability  Antiviral Effect