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Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction 期刊论文
European Journal of Medicinal Chemistry, 2017, 卷号: 125, 期号: X, 页码: 1051-1063
作者:  Zhang FH;  Debnath B;  Zheng YT;  Neamati N*;  Long YQ*;  Xu ZL;  Yang LM;  Song LR;  neamati@umich.edu
Adobe PDF(2261Kb)  |  收藏  |  浏览/下载：123/2  |  提交时间：2016/11/07
3-hydroxypicolinamide  Allosteric Inhibitor  Dimerization  Hiv-1 Integrase  Ledgf/p75  
Synthesis and Anti-HIV-1 Activity Evaluation for Novel 3a,6a-Dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-dione Derivatives 期刊论文
Molecules, 2016, 卷号: 21, 期号: 9, 页码: e1198
作者:  Liu GN;  Luo RH;  Yang LM;  Zheng YT*;  Liu H*;  Zhou Y;  Zhang XJ;  Li J;  zhengyt@mail.kiz.ac.cn;  hliu@mail.shcnc.ac.cn
Adobe PDF(848Kb)  |  收藏  |  浏览/下载：119/4  |  提交时间：2016/09/18
Aids  Sar  Anti-hiv-1  Integrase  Synthesis  
Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 12, 页码: 3146-3158
作者:  Li BW;  Zhang FH;  Serrao E;  Chen H;  Sanchez TW;  Yang LM;  Neamati N;  Zheng YT;  Wang H*;  Long YQ*;  huiwang@scnu.edu.cn;  yqlong@mail.shcnc.ac.cn
Adobe PDF(1380Kb)  |  收藏  |  浏览/下载：321/2  |  提交时间：2014/10/15
Chelation  Strand Transfer  Ledgf/p75  Hiv-1 Integrase Inhibitors  Flavonoid  
Discovery of a novel HIV-1 integrase inhibitor from natural compounds through structure based virtual screening and cell imaging 期刊论文
FEBS LETTERS, 2014, 卷号: 588, 期号: 18, 页码: 3461-3468
作者:  Gu WG;  Zhang X;  Ip DTM;  Yang LM;  Zheng YT;  Wan DCC*;  chicheongwan@cuhk.edu.hk
Adobe PDF(2283Kb)  |  收藏  |  浏览/下载：134/3  |  提交时间：2014/10/10
Hiv-1 Integrase  Lens Epithelium-derived Growth Factor (Ledgf/p75)  Virtual Screening  
1,4-Bis(5-(naphthalen-1-yl)thiophen-2-yl)naphthalene, a small molecule, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular Lens epithelium-derived growth factor 期刊论文
CHEMICO-BIOLOGICAL INTERACTIONS, 2014, 卷号: 213, 期号: X, 页码: 21-27
作者:  Gu WG;  Ip DTM;  Liu SJ;  Chan JH;  Wang Y;  Zhang X;  Zheng YT;  Wan DCC*;  chicheongwan@cuhk.edu.hk
Adobe PDF(1448Kb)  |  收藏  |  浏览/下载：102/2  |  提交时间：2014/10/15
Hiv-1 Integrase  Lens Epithelium-derived Growth Factor (Ledgf/p75  Molecular Docking  
Wikstroelide M potently inhibits HIV replication by targeting reverse transcriptase and integrase nuclear translocation 期刊论文
Chinese Journal of Natural Medicines, 2014, 卷号: 12, 期号: 3, 页码: 186-193
作者:  Zhang X;  Huang SZ;  Gu WG;  Yang LM;  Chen H;  Zheng CB;  Zhao YX;  Wan David DC;  Zheng YT*;  zhengyt@mail.kiz.ac.cn
Adobe PDF(1209Kb)  |  收藏  |  浏览/下载：5640/3  |  提交时间：2014/06/03
Wikstroelide m  Daphnane Diterpene  Daphne Acutiloba Rehder  Hiv  Reverse Trascriptase  Integrase  Nuclear Translocation  Lens Epithelium-derived Growth Factor (Ledgf/p75)  Molecular Docking  
Synthesis and biological evaluation of 5-fluoroquinolone-3-carboxylic acids as potential HIV-1 integrase inhibitors 期刊论文
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2013, 卷号: 28, 期号: 4, 页码: 671-676
作者:  He QQ;  Zhang X;  Yang LM;  Zheng YT;  Chen F*;  rfchen@fudan.edu.cn
Adobe PDF(782Kb)  |  收藏  |  浏览/下载：100/3  |  提交时间：2013/08/27
Hiv-1 Integrase Inhibitor  5-fluoroquinolone-3-carboxylic Acids  Anti-hiv Activity  Metal Chelating  Structure-activity Relationship  
Structural modifications of 5,6-dihydroxypyrimidines with anti-HIV activity 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 卷号: 22, 期号: 23, 页码: 7114-7118
作者:  Guo DL;  Zhang XJ;  Wang RR;  Zhou Y;  Li Z;  Xu JY;  Chen KX;  Zheng YT*;  Liu H*;  zhengyt@mail.kiz.ac.cn;  hliu@mail.shcnc.ac.cn
Adobe PDF(766Kb)  |  收藏  |  浏览/下载：119/2  |  提交时间：2013/04/09
Dihydroxypyrimidine  Synthesis  Hiv  Integrase Inhibitor  Docking Study  
Structural modifications of quinolone-3-carboxylic acids with anti-HIV activity 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 卷号: 19, 期号: 16, 页码: 5039-5045
作者:  He QQ;  Gu SX;  Liu J;  Wu HQ;  Zhang X;  Yang LM;  Zheng YT;  Chen FE*;  rfchen@fudan.edu.cn
Adobe PDF(366Kb)  |  收藏  |  浏览/下载：1670/4  |  提交时间：2011/08/26
Hiv  Integrase Inhibitor  Quinolone-3-carboxylic Acids  Two-metal Chelating Mechanism  
Synthesis and biological evaluation of HQCAs with aryl or benzyl substituents on N-1 position as potential HIV-1 integrase inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 卷号: 19, 期号: 18, 页码: 5553-5558
作者:  He QQ;  Zhang X;  Wu HQ;  Gu SX;  Ma XD;  Yang LM;  Zheng YT;  Chen FE[*];  rfchen@fudan.edu.cn
Adobe PDF(320Kb)  |  收藏  |  浏览/下载：1626/4  |  提交时间：2011/09/23
Hiv  Integrase Inhibitor  Quinolone-3-carboxylic Acids  Two-metal Chelating Mechanism  Structure-activity Relationships