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Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction 期刊论文
European Journal of Medicinal Chemistry, 2017, 卷号: 125, 期号: X, 页码: 1051-1063
作者:  Zhang FH;  Debnath B;  Zheng YT;  Neamati N*;  Long YQ*;  Xu ZL;  Yang LM;  Song LR;  neamati@umich.edu
Adobe PDF(2261Kb)  |  收藏  |  浏览/下载：126/2  |  提交时间：2016/11/07
3-hydroxypicolinamide  Allosteric Inhibitor  Dimerization  Hiv-1 Integrase  Ledgf/p75  
Synthesis and biological evaluation of 5-fluoroquinolone-3-carboxylic acids as potential HIV-1 integrase inhibitors 期刊论文
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2013, 卷号: 28, 期号: 4, 页码: 671-676
作者:  He QQ;  Zhang X;  Yang LM;  Zheng YT;  Chen F*;  rfchen@fudan.edu.cn
Adobe PDF(782Kb)  |  收藏  |  浏览/下载：101/3  |  提交时间：2013/08/27
Hiv-1 Integrase Inhibitor  5-fluoroquinolone-3-carboxylic Acids  Anti-hiv Activity  Metal Chelating  Structure-activity Relationship  
Structural modifications of 5,6-dihydroxypyrimidines with anti-HIV activity 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 卷号: 22, 期号: 23, 页码: 7114-7118
作者:  Guo DL;  Zhang XJ;  Wang RR;  Zhou Y;  Li Z;  Xu JY;  Chen KX;  Zheng YT*;  Liu H*;  zhengyt@mail.kiz.ac.cn;  hliu@mail.shcnc.ac.cn
Adobe PDF(766Kb)  |  收藏  |  浏览/下载：120/2  |  提交时间：2013/04/09
Dihydroxypyrimidine  Synthesis  Hiv  Integrase Inhibitor  Docking Study  
Structural modifications of quinolone-3-carboxylic acids with anti-HIV activity 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 卷号: 19, 期号: 16, 页码: 5039-5045
作者:  He QQ;  Gu SX;  Liu J;  Wu HQ;  Zhang X;  Yang LM;  Zheng YT;  Chen FE*;  rfchen@fudan.edu.cn
Adobe PDF(366Kb)  |  收藏  |  浏览/下载：1673/4  |  提交时间：2011/08/26
Hiv  Integrase Inhibitor  Quinolone-3-carboxylic Acids  Two-metal Chelating Mechanism  
Synthesis and biological evaluation of HQCAs with aryl or benzyl substituents on N-1 position as potential HIV-1 integrase inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 卷号: 19, 期号: 18, 页码: 5553-5558
作者:  He QQ;  Zhang X;  Wu HQ;  Gu SX;  Ma XD;  Yang LM;  Zheng YT;  Chen FE[*];  rfchen@fudan.edu.cn
Adobe PDF(320Kb)  |  收藏  |  浏览/下载：1627/4  |  提交时间：2011/09/23
Hiv  Integrase Inhibitor  Quinolone-3-carboxylic Acids  Two-metal Chelating Mechanism  Structure-activity Relationships  
Symmetrical 1-pyrrolidineacetamide showing anti-HIV activity through a new binding site on HIV-1 integrase 期刊论文
ACTA PHARMACOLOGICA SINICA, 2008, 卷号: 29, 期号: 10, 页码: 1261-1267
作者:  Du L;  Zhao YX;  Yang LM;  Zheng YT;  Tang Y[*];  Shen X[*];  Jiang HL;  ytang234@ecust.edu.cn;  xshen@mail.shcnc.ac.cn
Adobe PDF(1145Kb)  |  收藏  |  浏览/下载：149/6  |  提交时间：2010/08/24
Hiv-1 Integrase Inhibitor  Surface Plasma Resonance  Molecular Docking  Site-directed Mutagenesis  
Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 卷号: 18, 期号: 16, 页码: 4521-4524
作者:  Zeng LF;  Zhang HS;  Wang YH;  Sanchez T;  Zheng YT;  Neamati N;  Long YQ*;  yqlong@mail.shcnc.ac.cn
Adobe PDF(267Kb)  |  收藏  |  浏览/下载：118/3  |  提交时间：2010/08/24
Hiv-1 Integrase Inhibitor  Bioisostere  Heteroaromatic Carboxylic Acid  Isoxazole  Isothiazole  1h-pyrazole  Bioavailability  Antiviral Effect  
Synthesis and HIV-1 integrase inhibition activity of some N-arylindoles 期刊论文
CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, 卷号: 56, 期号: 5, 页码: 720-722
作者:  Xu H*;  Liu WQ;  Fan LL;  Chen Y;  Yang LM;  Lv L;  Zheng YT*;  orgxuhui@nwsuaf.edu.cn;  zhengyt@mail.kiz.ac.cn
Adobe PDF(81Kb)  |  收藏  |  浏览/下载：100/5  |  提交时间：2010/08/24
N-arylindole  Anti-human Immunodeficiency Virus Type 1  Integrase Inhibitor  Synthesis